Nitrogen balance studies in humans: long-term effect of high nitrogen intake on nitrogen accretion.
Nitrogen balance studies in humans: long-term effect of high nitrogen intake on nitrogen accretion.
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人体氮平衡研究：高氮摄入对氮积累的长期影响。
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
S. Margen
中科院分区：
文献类型：
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作者：
E. A. Oddoye;S. Margen
六名健康的年轻成年男性参与者被限制在代谢病房105天。两个营养充足的纯化饮食提供12和36克氮，每天被随机分为两个代谢期约50天。本研究的目的是验证在最严格控制的条件下，正氮平衡是否伴随着氮摄入量的增加，如果是这样，如果实验进行足够长的时间，是否会发生适应。平均氮平衡是轻微的负大多数参与者时，喂食12克氮饮食。然而，个体差异如此之大，以至于在统计学上所有参与者都可以被认为是平衡的。有鉴于此，我们同意其他研究人员的建议，即应将平衡视为一个考虑到诸如摄入量、输出量和生物因素等可变性的领域。在36 g N饮食中，所有参与者都表现出强烈的正平衡，约为1.6 g/天，这并不像其他研究人员报告的那样高，但只要他们被喂食这种饮食，就会持续存在。这种正平衡似乎不能用方法学错误或任何未测量的氮损失来解释。并没有如所声称的那样出现明显的适应趋势。
Six healthy young adult male participants were confined to a metabolic ward for 105 days. Two nutritionally adequate purified diets providing 12 and 36 g of nitrogen per day were randomized in two metabolic periods of approximately 50 days each. The objective of this study was to verify whether or not positive nitrogen balance is a concomitant of increased nitrogen intake under the most rigorously controlled conditions, and if so, whether adaptation could occur if the experiment was conducted for sufficiently long periods of time. The mean nitrogen balance was slightly negative for most participants when fed the 12 g N diet. However, individual variability was so large that statistically all the participants can be considered in balance. In view of this, we agree with other investigators who have suggested that balance should be considered as an area which takes into account variabilities such as intake, output and biological factors. On the 36 g N diet, all the participants exhibited strong positive balances, about 1.6 g/day, which were not as high as reported by other investigators but which persisted for as long as they were fed this diet. This positive balance could not seem to be explained on the basis of methodological errors or to any unmeasured nitrogen losses. There was no significant trend towards adaptation as claimed.