Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β
Transforming growth factor β2 autocrinally mediates neuronal cell death induced by amyloid-β
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DOI：
10.1002/jnr.20804
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发表时间：
2006-05-01
影响因子：
4.2
通讯作者：
Matsuoka, M
中科院分区：
文献类型：
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作者：
Hashimoto, Y;Nawa, M;Matsuoka, M
β淀粉样蛋白（Aβ）是阿尔茨海默病老年斑的主要成分，与神经元细胞死亡有关。我们发现，Aβ42（Aβ肽的神经毒性形式）可诱导神经元和神经胶质细胞表达TGFβ2。我们进一步证明，在培养基中添加TGFβ2中和抗体或大量重组可溶性淀粉样前体蛋白α（由α产生的淀粉样前体蛋白（APP）的胞外结构域）。分泌酶，抑制体外由 A beta 42 诱导的原代皮质神经元 (PCN) 死亡。结合我们最近的研究发现，TGF beta 2 是 APP 的神经元细胞死亡诱导配体，表明 TGF beta 2 是 PCN 中 A beta 42 诱导死亡的自分泌介质。 (c) 2006 Wiley-Liss, Inc.
Amyloid beta (A beta), the major component of the senile plaques of Alzheimer's disease, is implicated in neuronal cell death. We have found that A beta 42, a neurotoxic form of A beta peptide, induces both neuronal and glial expression of TGF beta 2. We have further demonstrated that the addition into culture media of neutralizing antibody to TGF beta 2 or a large amount of the recombinant soluble amyloid precursor protein alpha, the extracellular domain of amyloid precursor protein (APP) generated by a. secretase, suppresses death in primary cortical neurons (PCNs) induced by A beta 42 in vitro. Combined with the finding in our recent study indicating that TGF beta 2 is a neuronal cell death-inducing ligand for APP, it is suggested that TGF beta 2 is an autocrinal mediator for A beta 42-induced death in PCNs. (c) 2006 Wiley-Liss, Inc.