EFFECTS OF REARING KITTENS WITH CONVERGENT STRABISMUS ON DEVELOPMENT OF RECEPTIVE-FIELD PROPERTIES IN STRIATE CORTEX NEURONS
EFFECTS OF REARING KITTENS WITH CONVERGENT STRABISMUS ON DEVELOPMENT OF RECEPTIVE-FIELD PROPERTIES IN STRIATE CORTEX NEURONS
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DOI：
10.1152/jn.1983.50.1.265
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发表时间：
1983-01-01
影响因子：
2.5
通讯作者：
BANSER, FA
中科院分区：
文献类型：
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作者：
CHINO, YM;SHANSKY, MS;BANSER, FA
手术诱导会聚性斜视在7只小猫在3周龄。记录在131个细胞中的纹状皮质的这些斜视小猫成熟后，结果进行了比较，从正常饲养的猫的140个纹状神经元的数据。所有样品的感受野（RF）均在5 °以内。中央区域的。利用不同对比度、不同空间频率和时间频率的漂移正弦光栅，定量分析了其空间和时间响应特性。与其他报道相反，只由斜视眼驱动或支配的纹状体神经元的感受场特性是相当异常的。斜视猫的空间频率调谐曲线与正常猫的不同之处在于，最佳空间频率和空间分辨率向较低值偏移，带宽明显变宽。对比度响应函数表明，在最佳空间频率下测量的对比度阈值显着较高，斜视动物的函数斜率更平坦。感受野的大小要大得多，方向调谐的锐度降低斜视猫。然而，方向选择性在这些动物中是正常的。时间频率调谐曲线也异常，特别是在时间分辨率大大降低，在斜视猫与正常饲养的猫相比。此外，斜视动物的许多细胞对视觉和视交叉（OX）刺激表现出更长的潜伏期。所有这些影响也被观察到的条纹单位控制的不偏离的眼睛，虽然改变的幅度取决于接收场的属性。在空间频率调谐，对比度阈值和RF大小发现的异常是严重的偏离眼中所揭示的。对其他RF特性的影响很小或不太严重。这些生理发现与其他地方报道的相同猫的空间对比敏感度的行为测量结果非常一致。显然，会聚性斜视动物（或许还有人类）的不偏斜眼不应该总是被认为是正常的。
Convergent strabismus was induced surgically in 7 kittens at 3 wk of age. Recordings were made in 131 cells in the striate cortex of these strabismic kittens after maturation, and the results were compared to the data obtained from 140 striate neurons in normally reared cats. All samples had receptive fields (RF) within 5.degree. of the area centralis. The spatial and temporal response properties were quantitatively analyzed by using drifting sinusoidal gratings of various contrasts as well as spatial and temporal frequencies. In contrast to other reports, the receptive-field properties of the striate neurons exclusively driven or dominated by the deviating eye were quite abnormal. The spatial frequency tuning curves in strabismic cats were different from those obtained from normals in that the optimal spatial frequencies and spatial resolutions were shifted to lower values and the bandwidths were significantly broader. The contrast-response functions show that contrast thresholds, measured at the optimal spatial frequency, were significantly higher and the slope of the functions much flatter in strabismic animals. Receptive-field sizes were much larger and the sharpness of orientation tuning was reduced in strabismic cats. Direction selectivity, however, was normal in those animals. The temporal frequency tuning curves were also abnormal, particularly in that temporal resolution was considerably reduced in strabismic cats compared with normally reared cats. In addition, many cells in strabismic animals exhibited much longer latencies to visual and optic chiasm (OX) stimulations. All these effects were also observed in the striate units controlled by the nondeviating eye, although the magnitude of the alteration depends on the receptive-field property. The abnormalities found in spatial frequency tuning, contrast thresholds and RF sizes were as severe as those revealed in the deviating eye. The effects on other RF properties were minimal or less severe. These physiological findings correspond very well with results from behavioral measurements of spatial contrast sensitivity in the same cats reported elsewhere. Evidently, the nondeviating eye in convergent strabismic animals, and perhaps humans, should not always be presumed normal.