Electrical stimulation of the sacral dorsal gray commissure evokes relaxation of the external urethral sphincter in the cat
Electrical stimulation of the sacral dorsal gray commissure evokes relaxation of the external urethral sphincter in the cat
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DOI：
10.1016/s0304-3940(98)00382-6
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发表时间：
1998-06-12
影响因子：
2.5
通讯作者：
Holstege, G
中科院分区：
文献类型：
--
作者：
Blok, BFM;van Maarseveen, JTPW;Holstege, G
刺激脑桥排尿中心(PMC)导致排尿，即立即松弛尿道括约肌和收缩膀胱逼尿肌。PMC通过一种直接的兴奋通路产生膀胱收缩，该通路到达骶髓中的副交感膀胱运动神经元。其想法是，PMC通过直接投射到背侧灰质连合(DGC)中的GABA能神经元来产生尿道括约肌的松弛，而GABA能神经元反过来又抑制尿道括约肌运动神经元。根据这一假设，三只猫的DGC中的电刺激应该导致尿道括约肌的松弛。结果与这一概念完全一致。在DGC刺激过程中，尿路压力急剧下降，其强度完全依赖于电刺激的幅度。(C)1998爱思唯尔爱尔兰科学有限公司。保留所有权利。
Stimulation of the pontine micturition center (PMC) results in micturition, i.e. an immediate relaxation of the urethral sphincter and a contraction of the detrusor muscle of the bladder. The PMC generates the bladder contraction by way of a direct excitatory pathway to the parasympathetic bladder motoneurons in the sacral cord. The idea is that the PMC produces the relaxation of the urethral sphincter via direct projections to GABAergic neurons in the dorsal gray commissure (DGC), which, in turn, inhibit the urethral sphincter motoneurons. According to this hypothesis, electrical stimulation in the DGC in three cats should result in relaxation of the urethral sphincter. The results were in total agreement with this concept. During DGC stimulation a sharp decrease of the urethral pressure was found, the strength of which depended completely on the amplitude of the electrical stimulation. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.