Retrieving meaning after temporal lobe infarction: The role of the basal language area
Retrieving meaning after temporal lobe infarction: The role of the basal language area
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DOI：
10.1002/ana.20294
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发表时间：
2004-12-01
影响因子：
11.2
通讯作者：
Wise, RJS
中科院分区：
文献类型：
--
作者：
Sharp, DJ;Scott, SK;Wise, RJS
在言语理解过程中，位于上级颞叶皮层的听觉关联皮层参与对言语信号的感知分析，而位于颞叶皮层下部的基础语言区则介导对词义的获取。上级和下部颞叶皮质之间相互作用的中断是决定失语性卒中恢复的因素之一。我们使用正电子发射断层扫描，以调查语义加工在下颞叶皮层在对照组和梗死后涉及上级颞叶皮层。在对照组中，清晰语音的语义决策激活了两个前梭状回。慢性失语症患者在任务中受损，并表现出左前梭状回激活减少。当对照组听到感知退化的语音时，观察到类似的表现受损和左前梭状回激活减少的模式。两组的表现都预测了右前梭状回和颞极的活动，准确性与活动呈线性相关。这些结果表明，基础语言区的功能是敏感的知觉输入的质量的变化。此外，在每个半球观察到不同的配置文件的反应表明不同的贡献，左，右下颞叶皮层的语音语义处理。
During speech comprehension the auditory association cortex in the superior temporal cortex is involved in perceptual analysis of the speech signal, whereas the basal language area in the inferior temporal cortex mediates access to word meaning. Disruption of the interaction between the superior and inferior temporal cortices is one factor that may determine recovery from aphasic stroke. We used positron emission tomography to investigate semantic processing within inferior temporal cortex in control subjects and after infarction involving the superior temporal cortex. In the control group, semantic decision making on clear speech activated both anterior fusiform gyri. Chronic aphasic patients were impaired at the task and demonstrated reduced activation within the left anterior fusiform gyrus. A similar pattern of impaired performance and reduced left anterior fusiform gyrus activation was observed when control subjects heard perceptually degraded speech. Performance in both groups predicted activity in the right anterior fusiform gyrus and the temporal poles, where accuracy linearly correlated with activity. These results demonstrate that the function of the basal language area is sensitive to changes in the quality of perceptual input. In addition, different profiles of response observed in each hemisphere suggest distinct contributions of both left and right inferior temporal cortices to the semantic processing of speech.