Infection with Wolbachia protects mosquitoes against Plasmodium-induced mortality in a natural system
Infection with Wolbachia protects mosquitoes against Plasmodium-induced mortality in a natural system
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DOI：
10.1111/j.1420-9101.2012.02519.x
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发表时间：
2012-07-01
影响因子：
2.1
通讯作者：
Rivero, A.
中科院分区：
文献类型：
--
作者：
Zele, F.;Nicot, A.;Rivero, A.
近年来，随着人们认识到，在该领域，大多数宿主都被多种寄生虫共同感染，一种宿主-一种寄生虫的模式发生了转变。当宿主是疾病的媒介时，合并感染特别相关，因为多重感染在生态和进化时间尺度上都可能对寄生虫传播产生严重后果。Wolbachia pipientis是昆虫中最常见的寄生微生物，因此，它对于了解寄生虫感染结果中的混合感染的作用具有特殊意义。在这里，我们调查沃尔巴克氏体是否可以调节疟原虫的影响，可以说，蚊子的媒介能力的最重要组成部分：他们的寿命。为了这个目的，并在最近的研究集中在蚊子疟原虫和/或蚊子沃尔巴克氏体组合没有发现在自然界中，我们的工作在一个沃尔巴克氏体squitoPlasmodium三联体具有共同的进化历史。我们的研究结果表明，沃尔巴克氏体保护蚊子免受疟原虫诱导的死亡。结果在两种不同的沃尔巴克氏体菌株中是一致的，并且在两个不同的实验块中是可重复的。据我们所知，这是第一次对受疟原虫感染的蚊子，特别是天然沃尔巴克氏体宿主组合显示出这种效果。我们讨论了不同的机制和进化的解释，这些结果以及其后果疟原虫传播。
In recent years, there has been a shift in the one host-one parasite paradigm with the realization that, in the field, most hosts are coinfected with multiple parasites. Coinfections are particularly relevant when the host is a vector of diseases, because multiple infections can have drastic consequences for parasite transmission at both the ecological and evolutionary timescales. Wolbachia pipientis is the most common parasitic microorganism in insects, and as such, it is of special interest for understanding the role of coinfections in the outcome of parasite infections. Here, we investigate whether Wolbachia can modulate the effect of Plasmodium on what is, arguably, the most important component of the vectorial capacity of mosquitoes: their longevity. For this purpose, and in contrast to recent studies that have focused on mosquitoPlasmodium and/or mosquitoWolbachia combinations not found in nature, we work on a WolbachiamosquitoPlasmodium triad with a common evolutionary history. Our results show that Wolbachia protects mosquitoes from Plasmodium-induced mortality. The results are consistent across two different strains of Wolbachia and repeatable across two different experimental blocks. To our knowledge, this is the first time that such an effect has been shown for Plasmodium-infected mosquitoes and, in particular, in a natural Wolbachiahost combination. We discuss different mechanistic and evolutionary explanations for these results as well as their consequences for Plasmodium transmission.