Studies of uptake of the bretylium analogue, iodobenzyltrimethylammonium iodide, by non-primate, monkey and human hearts.
Studies of uptake of the bretylium analogue, iodobenzyltrimethylammonium iodide, by non-primate, monkey and human hearts.
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研究非灵长类动物、猴子和人类心脏对溴苄基类似物碘苄基三甲基碘化铵的吸收。
DOI：
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发表时间：
1979
影响因子：
3.4
通讯作者：
J. Tyson
中科院分区：
文献类型：
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作者：
E. Carr;M. Carroll;R. Counsell;J. Tyson
用Langendorff法研究了大鼠心脏对（+/-）-[~ 3 H]-去甲肾上腺素、[~（14）C]-溴苄铵和[~（125）I]-O-碘苄基三甲基碘化铵（RIBA）的摄取。所有三种化合物均显示出显著的吸收。2皮质酮和17-β-雌二醇抑制大鼠心脏对所有三种化合物的摄取，这一发现与神经元摄取（摄取2）一致。3.将[131 I]-RIBA静脉注射到猪和猴（M. speciosus）。从注射后1和2小时处死的猪中采集的心肌样品显示出显著的摄取。注射后10 min、2 h和24 h处死的猴心肌样品中未发现明显摄取。4四名正常志愿者静脉注射[125 I]-RIBA，注射后前4小时通过闪烁照相机跟踪心前区的图像。在其中两名受试者中，分别在注射后22和23 h重复进行了心电图检查。未观察到心肌摄取的证据。5这些结果表明，人类和至少一种其他灵长类物种在吸收方面可能与低等物种不同。
Uptake of (+/-)-[3H]-noradrenaline, [14C]-bretylium and [125I]-o-iodobenzyltrimethylammonium iodide (RIBA) by rat heart was studied by the Langendorff technique. All three compounds showed significant uptake. 2 Corticosterone and 17-beta-oestradiol inhibited the uptake of all three compounds by rat heart, a finding consistent with extraneuronal uptake (uptake2). 3 [131I]-RIBA was injected intravenously into pigs and monkeys (M. speciosus). Myocardial samples taken from pigs killed 1 and 2 h after injection showed significant uptake. No significant uptake was found in myocardial samples of monkeys killed 10 min, 2 h and 24 h, respectively, after injection. 4 Four normal human volunteers received [125I]-RIBA intravenously and the image of the precordial area was followed by means of scintillation camera for the first 4 h after injection. In two of the subjects, the scintigrams were repeated at 22 and 23 h after injection, respectively. No evidence of myocardial uptake was observed. 5 These results suggest the possibility that man and at least one other primate species may differ from lower species with regard to uptake.