Diclofenac sodium delivery to the eye:: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
Diclofenac sodium delivery to the eye:: In vitro evaluation of novel solid lipid nanoparticle formulation using human cornea construct
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DOI：
10.1016/j.ijpharm.2007.12.007
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发表时间：
2008-05-01
影响因子：
5.8
通讯作者：
Mueller-Goymann, Christel C.
中科院分区：
文献类型：
--
作者：
Attama, Anthony A.;Reichl, Stephan;Mueller-Goymann, Christel C.
用山羊脂肪同脂和磷脂复合制备固体脂质纳米粒(SLN)，并用永生化人角膜内皮细胞(HENC)、基质成纤维细胞和上皮细胞CEPI17Cl4制备生物工程人角膜，评价双氯芬酸钠(DNA)眼部给药的效果。实验结果表明，磷脂修饰的SLN制剂可提高DNA在角膜结构中的渗透性。(C)2007 Elsevier B.V.保留所有权利。
Solid lipid nanoparticles (SLNs) were prepared with a combination of homolipid from goat (goat fat) and phospholipid, and evaluated for diclofenac sodium (DNa) delivery to the eye using bio-engineered human cornea, produced from immortalized human corneal endothelial cells (HENC), stromal fibroblasts and epithelial cells CEPI 17 CL 4. Encapsulation efficiency was high and sustained release of DNa and high permeation through the bio-engineered cornea were achieved. Results obtained in this work showed that permeation of DNa through the cornea construct was improved by formulation as SLN modified with phospholipid. (C) 2007 Elsevier B.V. All rights reserved.