Extracellular vesicles as delivery systems at nano-/micro-scale.
Extracellular vesicles as delivery systems at nano-/micro-scale.
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DOI：
10.1016/j.addr.2021.113910
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发表时间：
2021-12
影响因子：
16.1
通讯作者：
Tao Z
中科院分区：
文献类型：
--
作者：
Fu P;Zhang J;Li H;Mak M;Xu W;Tao Z
细胞外囊泡（EVs）作为纳米/微米尺寸的载体在药物递送和生物成像中显示出显著的前景。通过大量的研究工作探索了电动汽车的更多特性，其无与伦比的理化性质，生物学特性和机械方面使其成为独特的载体，在输送治疗诊断货物时具有特殊的药代动力学，循环代谢和生物分布模式。在这篇综述中，我们首先分析了电动汽车作为交付平台的优点和缺点。其次，与工程化纳米颗粒递送系统（例如生物相容性二嵌段共聚物）相比，阐述了改善EV（特别是外来体）的合理设计。最后，比较了电动汽车中不同的药物装载方法，得出了如何构建临床可用且有效的纳米/微载体以执行令人满意的医疗使命的结论。天然细胞外囊泡与人工颗粒在通往下一代药物递送系统的途中的示意图。
Extracellular vesicles (EVs) have shown significant promises as nano-/micro-size carriers in drug delivery and bioimaging. With more characteristics of EVs explored through tremendous research efforts, their unmatched physicochemical properties, biological features, and mechanical aspects make them unique vehicles, owning exceptional pharmacokinetics, circulatory metabolism and biodistribution pattern when delivering theranostic cargoes. In this review we firstly analyzed pros and cons of the EVs as a delivery platform. Secondly, compared to engineered nanoparticle delivery systems, such as biocompatible di-block co-polymers, rational design to improve EVs (exosomes in particular) were elaborated. Lastly, different pharmaceutical Loading approaches into EVs were compared, reaching a conclusion on how to construct a clinically available and effective nano-/micro-carrier for a satisfactory medical mission. Schematic illustrations of natural extracellular vesicles versus artificial particles en route to a next-generation drug delivery system.
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影响因子：
46.9
作者：
Alvarez-Erviti, Lydia;Seow, Yiqi;Wood, Matthew J. A.
通讯作者：
Wood, Matthew J. A.
DOI：
10.1016/j.nano.2017.03.001
发表时间：
2017-07-01
影响因子：
5.4
作者：
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通讯作者：
Gupta, Ramesh C.
影响因子：
8.6
作者：
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通讯作者：
Alvarez-Erviti, Lydia
影响因子：
17.1
作者：
Betzer, Oshra;Perets, Nisim;Popovtzer, Rachela
通讯作者：
Popovtzer, Rachela
影响因子：
4.2
作者：
Baruteau J;Waddington SN;Alexander IE;Gissen P
通讯作者：
Gissen P