New perspectives of curcumin in cancer prevention.
New perspectives of curcumin in cancer prevention.
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DOI：
10.1158/1940-6207.capr-12-0410
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发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Shin DM
中科院分区：
文献类型：
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作者：
Park W;Amin AR;Chen ZG;Shin DM
几十年来，许多天然化合物因其预防癌症的潜力而受到广泛研究。姜黄素是一种非常有前途的天然化合物，可用于多种癌症的化学预防。姜黄素调节参与漫长的致癌过程的多个分子途径，通过几种机制发挥其化学预防作用：促进细胞凋亡，抑制生存信号，清除活性氧化物质（ROS），减少炎症性癌症微环境。姜黄素具有毒性低、价格低廉、易获得等特点，是一种理想的化学预防剂。然而，姜黄素的临床应用目前受到其生物利用度差的影响。本文综述了姜黄素在癌症预防中的作用、作用靶点和作用机制。最后，我们提出了具体的建议，以提高其疗效和生物利用度的临床应用。
Numerous natural compounds have been extensively investigated for their potential for cancer prevention over decades. Curcumin, from Curcuma longa, is a highly promising natural compound that can be potentially used for chemoprevention of multiple cancers. Curcumin modulates multiple molecular pathways involved in the lengthy carcinogenesis process to exert its chemopreventive effects through several mechanisms: promoting apoptosis, inhibiting survival signals, scavenging reactive oxidative species (ROS), and reducing the inflammatory cancer microenvironment. Curcumin fulfills the characteristics for an ideal chemopreventive agent with its low toxicity, affordability, and easy accessibility. Nevertheless, the clinical application of curcumin is currently compromised by its poor bioavailability. Here we review the potential of curcumin in cancer prevention, its molecular targets, and action mechanisms. Finally, we suggest specific recommendations to improve its efficacy and bioavailability for clinical applications.