AGE-RELATED CHANGE IN SKELETAL-MUSCLE BLOOD-FLOW IN THE RAT
AGE-RELATED CHANGE IN SKELETAL-MUSCLE BLOOD-FLOW IN THE RAT
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DOI：
10.1093/geronj/42.6.660
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发表时间：
1987-11-01
期刊：
影响因子：
--
通讯作者：
TUMA, RF
中科院分区：
文献类型：
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作者：
IRION, GL;VASTHARE, US;TUMA, RF
采用示踪微球技术对麻醉的成年和衰老雄性Fischer 344大鼠进行足底屈肌原位刺激和血流量测量。在确定最佳长度和最大破伤风力后，刺激肌肉以120破伤风/分钟的速度收缩。衰老大鼠的肌肉血流量明显低于年轻大鼠，肌肉疲劳程度明显高于年轻大鼠。在静息麻醉大鼠中输注非特异性血管扩张剂也显示出衰老大鼠增加肌肉血流量的潜力显著降低。衰老大鼠在肌肉收缩过程中肌肉血流量减少可能是导致衰老雄性大鼠肌肉性能下降的原因，至少是部分原因。
Anesthetized adult and senescent male Fischer 344 rats were instrumented for stimulation of in situ plantar flexor muscles and blood flow measurement by the tracer microsphere technique. After determination of optimum length and maximum tetanic force, muscles were stimulated to contract at the rate of 120 tetani/min. Senescent rats displayed significantly lower muscle blood flow and greater muscle fatigue than younger rats. Infusion of a nonspecific vasodilator in resting anesthetized rats also revealed a significantly lower potential to increase muscle blood flow in the senescent rats. Lower muscle blood flow of senescent rats during muscle contractions might be responsible, at least in part, for decreased performance of muscles of senescent male rats.