Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants
Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants
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DOI：
10.1007/s00216-002-1694-z
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发表时间：
2003-02-01
影响因子：
4.3
通讯作者：
Hirner, AV
中科院分区：
文献类型：
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作者：
Flassbeck, D;Pfleiderer, B;Hirner, AV
已知乳房植入体中使用的硅[聚（二甲基硅氧烷）]凝胶会通过完整的硅橡胶弹性体壳体迁移，导致植入体表面出现临床可观察到的“凝胶渗出”。尽管已经用元素特异性硅分析测量了使用硅胶假体的女性的囊组织中的硅浓度，但是还没有对这些组织进行硅胶特异性研究。使用ICP-HR-IDMS和物种特异性气相色谱-质谱联用（GC-MS）分析假体囊、肌肉和脂肪组织中的含量，以及作为对照的非隆乳妇女（n = 3）的乳房组织中的含量。特别是八甲基环四硅氧烷（D4）、十甲基环五硅氧烷（D5）和十二甲基环六硅氧烷（D 6）。根据所分析的硅氧烷种类和组织类型，检测到的硅氧烷水平约为10- 1，400 ng g（-1）;在该范围内的所有组织样本中均发现了总硅。约8，900 - 85，000 ng g（-1）。在两名假体患者的纤维蛋白层和脂肪组织中检测到较高的铂水平，范围为25-90 ng g（-1）。在对照乳腺组织样本中未检测到硅氧烷。
Silicone [poly(dimethylsiloxane)] gel used in breast implants has been known to migrate through intact silicone elastomer shells, resulting in the clinically observable "gel bleed" on the implant surface. Although silicon concentrations in capsular tissues of women with silicone prostheses have been measured with element-specific silicon analyses, no silicone-specific investigation of these tissues has been performed as yet.A combination of element-specific inductively coupled plasma high-resolution isotope dilution mass spectrometry (ICP-HR-IDMS) and species-specific gas chromatography coupled mass spectrometry (GC-MS) was used to analyze silicon, platinum, and siloxanes in prosthesis capsule, muscle, and fat tissues of women (n=3) who had silicone gel-filled breast implants and in breast tissue of non-augmented women (n=3) as controls.In all tissues of augmented women, siloxanes,. in particular octamethylcyclotetrasiloxane,(D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclohexasiloxane (D6) were identified. Depending on the siloxane species and type of tissue analyzed, siloxane levels in the range of about 10-1,400 ng g(-1) were detected; total silicon was found in all tissue samples in the range. of about 8,900-85,000 ng g(-1). Higher platinum levels ranging from 25-90 ng g(-1) were detected in fibrin layer and fat tissue of two patients with prostheses. No siloxanes were detected in control breast tissue samples.