Biological Roles of Alternative Autophagy.
Biological Roles of Alternative Autophagy.
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DOI：
10.14348/molcells.2018.2215
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发表时间：
2018-01-31
影响因子：
3.8
通讯作者：
Shimizu S
中科院分区：
文献类型：
--
作者：
Shimizu S
ATG5和ATG7一直被认为是自噬的基本分子。然而，我们发现，缺乏这些分子的细胞在受到一定压力时仍然形成自噬空泡并进行自噬蛋白降解。在这一非传统的自噬途径中，自噬小体似乎是通过融合来自反式高尔基体的小泡和晚期内噬小体而以Rab9依赖的方式产生的。因此，哺乳动物的自噬至少可以通过两种不同的途径发生：依赖ATG5/ATG7的常规途径和不依赖ATG5/ATG7的替代途径。
Atg5 and Atg7 have long been considered as essential molecules for autophagy. However, we found that cells lacking these molecules still form autophagic vacuoles and perform autophagic protein degradation when subjected to certain stressors. During this unconventional autophagy pathway, autophagosomes appeared to be generated in a Rab9-dependent manner by the fusion of vesicles derived from the trans-Golgi and late endosomes. Therefore, mammalian autophagy can occur via at least two different pathways; the Atg5/Atg7-dependent conventional pathway and an Atg5/Atg7-independent alternative pathway.