K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.
K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse.
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DOI：
10.1126/science.2333511
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发表时间：
1990-05
期刊：
影响因子：
56.9
通讯作者：
A. Wei;Manuel Covarrubias;A. Butler;K. Baker;Michael D Pak;L. Salkoff
中科院分区：
文献类型：
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作者：
A. Wei;Manuel Covarrubias;A. Butler;K. Baker;Michael D Pak;L. Salkoff
果蝇X染色体上的Shaker基因有三个姊妹基因，分别是Shal、Shab和Shaw，分别位于第二和第三条染色体上。这个扩展的基因家族编码具有广泛变化的动力学（宏观电流激活和失活的速率）和稳态失活的电压敏感性的电压门控钾通道。不同基因产物电流的差异大于摇子基因的选择性剪接所产生的差异。在果蝇中，钾通道的瞬时（A电流）亚型（Shaker和Shal）和延迟整流亚型（Shab和Shaw）是由同源基因编码的，每种亚型通道都有不止一个基因。Shaker、Shal、Shab和Shaw的同系物存在于哺乳动物中；在哺乳动物中，每个果蝇钾通道基因都可以代表一个多基因亚家族。
The Drosophila Shaker gene on the X chromosome has three sister genes, Shal, Shab, and Shaw, which map to the second and third chromosomes. This extended gene family encodes voltage-gated potassium channels with widely varying kinetics (rate of macroscopic current activation and inactivation) and voltage sensitivity of steady-state inactivation. The differences in the currents of the various gene products are greater than the differences produced by alternative splicing of the Shaker gene. In Drosophila, the transient (A current) subtype of the potassium channel (Shaker and Shal) and the delayed-rectifier subtype (Shab and Shaw) are encoded by homologous genes, and there is more than one gene for each subtype of channel. Homologs of Shaker, Shal, Shab, and Shaw are present in mammals; each Drosophila potassium-channel gene may be represented as a multigene subfamily in mammals.