Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000-2003)
Geographic distribution of babesiosis among dogs in the United States and association with dog bites: 150 cases (2000-2003)
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DOI：
10.2460/javma.2005.227.942
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发表时间：
2005-09-15
影响因子：
1.9
通讯作者：
Breitschwerdt, EB
中科院分区：
文献类型：
--
作者：
Birkenheuer, AJ;Correa, MT;Breitschwerdt, EB
目的-确定美国犬类中巴贝斯虫病的地理分布，并确定除美国比特斗牛梗 (APBT) 之外的其他犬类，感染是否与最近的狗咬伤有关。设计回顾性研究。动物-150 只狗。程序-2000 年 5 月至 2003 年 10 月期间将犬血液样本提交给北卡罗来纳州立大学媒介传播疾病诊断实验室，对其进行巴贝斯虫特异性聚合酶链反应测定的结果鉴定呈阳性，并记录获取样本的狗的品种和地理来源，记录非 APBT 狗的病史和血液学异常，并检查与最近被狗咬伤的可能关联。结果 - 巴贝虫 DNA 呈阳性的狗分布在 29 个州和加拿大 1 个省（安大略省），吉氏巴贝虫是最常检测到的物种，在 144 份中的 131 份血液样本中检测到吉氏巴贝虫 DNA（91%）狗。在 131 只吉布氏杆菌 DNA 呈阳性的狗中，122 只 (93%) 是 APBT。在 10 只犬巴贝斯虫 DNA 呈阳性的狗中，有 6 只是灵缇犬。在除 APBT 以外的狗中，最近被另一只狗（尤其是 APBT）咬伤与吉布氏巴贝斯虫感染之间存在关联。结论和临床相关性结果记录了美国狗中巴贝斯虫病已知地理范围的扩大。对于具有与免疫介导的溶血性贫血或血小板减少症一致的临床病理学异常的狗，应进行巴贝斯虫病检测，特别是如果最近有狗咬伤史的话。
Objective-To identify the geographic distribution of babesiosis among dogs in the United States and determine, for dogs other than American Pit Bull Terriers (APBTs), whether infection was associated with a recent dog bite.Design-Retrospective study.Animals-150 dogs.Procedure-Canine blood samples submitted to the North Carolina State University Vector-Borne Disease Diagnostic Laboratory between May 2000 and October 2003 for which results of a Babesia-specific polymerase chain reaction assay were positive were identified, and breed and geographic origin of dogs from which samples were obtained were recorded, History and hematologic abnormalities for dogs that were not APBTs were recorded, and possible associations with a recent dog bite were examined.Results-Dogs positive for Babesia DNA were located in 29 states and 1 Canadian province (Ontario), Babesia gibsoni was the most commonly detected species, with B gibsoni DNA detected in blood samples from 131 of 144 (91%) dogs. Of the 131 dogs positive for B gibsoni DNA, 122 (93%) were APBTs. Of the 10 dogs positive for Babesia canis vogeli DNA, 6 were Greyhounds, In dogs other than APBTs, there was an association between having recently been bitten by another dog, particularly an APBT, and infection with B gibsoni.Conclusions and Clinical Relevance-Results document an expansion of the known geographic range for babesiosis among dogs in the United States. Testing for babesiosis should be pursued in dogs with clinicopathologic abnormalities consistent with immune-mediated hemolytic anemia or thrombocytopenia, particularly if there is a history of a recent dog bite.