The effects of three Drosophila melanogaster myotropins on the frequency of foregut contractions differ
The effects of three Drosophila melanogaster myotropins on the frequency of foregut contractions differ
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DOI：
10.1080/01677060213156
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发表时间：
2002-04-01
影响因子：
1.9
通讯作者：
Nichols, R
中科院分区：
文献类型：
--
作者：
Kaminski, S;Orlowski, E;Nichols, R
肌营养肽可以根据其结构分为不同的家族。三种果蝇肌营养素家族由TDVDHVFLRFamide、dromosuppressin（DMS）、pEVRYRQCYFNPISCF（一种名为flatline（FLT）的allatostatin C型肽）和SDNFMRFamide（一种含有FMRFamide的肽）代表。DMS、FLT和SDNFMRFamide的结构不同，并且每种肽由不同的基因编码。此外，DMS、FLT和SDNFMRFamide的时空分布是不同的。DMS、FLT和SDNFMRFamide各自降低心率;然而，它们的作用是完全不同的：同样，这三种肌营养素对前肠前部作物自发收缩频率的影响也不同。DMS在施用肽后至少10分钟内停止作物运动而没有恢复，FLT显著降低自发收缩的频率，但其作用在施用肽后几分钟内部分逆转，SDNFMRFamide仅轻微降低作物运动性，该作用与盐水的作用没有显著差异。DMS、FLT和SDNFMRFamide在结构、分布和活性上的差异表明它们的合成和释放是在不同的感觉输入和调节机制下进行的，并且它们在影响作物收缩频率方面的作用不同。
Myotropic peptides can be grouped into different families based on their structure. Three Drosophila melanogaster myotropin families are represented by TDVDHVFLRFamide, dromyosuppressin (DMS), pEVRYRQCYFNPISCF, an allatostatin C-type peptide named flatline (FLT), and SDNFMRFamide, a FMRFamide-containing peptide. The structures of DMS, FLT, and SDNFMRFamide differ and each peptide is encoded by a different gene. In addition, the spatial and temporal distributions of DMS, FLT, and SDNFMRFamide are dissimilar. DMS, FLT, and SDNFMRFamide each decreases heart rate; however, their effects are profoundly different: Likewise, the effects of these three myotropins on the frequency of the spontaneous contractions of the crop, an anterior portion of the foregut, differ. DMS stops crop movement without recovery for at least a 10-min period after applying the peptide, FLT significantly decreases the frequency of spontaneous contractions, but its effect partially reverses within a few minutes after applying the peptide, and SDNFMRFamide only slightly decreased crop motility, an effect that was not significantly different from the effect of saline. The differences in the structures, distributions, and activities of DMS, FLT, and SDNFMRFamide suggest their synthesis and release are under different sensory inputs and regulatory mechanisms, and that roles in affecting the frequency of crop contractions differ.