Dog thyroiditis: occurrence and similarity to Hashimoto's struma.
Dog thyroiditis: occurrence and similarity to Hashimoto's struma.
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狗甲状腺炎：与桥本甲状腺肿的发生和相似性。
DOI：
10.1210/endo-83-3-501
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发表时间：
1968
期刊：
影响因子：
4.8
通讯作者：
Ronald H. Nishiyama
中科院分区：
文献类型：
--
作者：
William H. Beierwaltes;Ronald H. Nishiyama
组织学证明，在1958年开始的一个纯种小猎犬群体中，541只雄性中12.5%的人和440只雌性中10.9%的人患上了与人类桥本甲状腺肿难以区分的甲状腺炎。大多数受影响的狗是461号狗的后代。种马“I”的使用使患病率增加了一倍多。在同一设施中的一组非殖民地购买的比格犬中，336只雄性中有4%患有甲状腺炎，408只雌性中有3%患有甲状腺炎。我们研究了11只成年群体犬，11只购买的对照成年犬，4窝纯种群体犬和16只对照纯种比格犬幼崽。在人类甲状腺中发现的桥本氏甲状腺肿的整个范围的组织学参与仅见于纯种繁殖群体的成年狗。只有3只甲状腺组织病理最严重的狗在低碘饮食下血清PbI值降至1.0μg/100ml，~(131)I摄取低于正常，注射~(131)I的甲状腺摄取百分率对促甲状腺激素的反应低于正常。一只带着你的狗..。
Histologically proved thyroiditis indistinguishable from human Hashimoto’s struma was found to occur in 12.5 % of 541 males and 10.9% of 440 females in a purebred beagle colony started in 1958. Most affected dogs descended from dog 461. The use of stud “I” more than doubled the prevalence. Among a noncolony purchased group of beagles in the same facilities, 4% of 336 males and 3% of 408 females had thyroiditis. We have studied 11 of the adult colony dogs, 11 purchased control adult dogs, 4 litters of the purebred colony and 16 control purebred beagle pups. Histologic involvement covering the entire gamut of Hashimoto’s struma seen in human thyroid glands was seenonly in the adult dogs of the purebred breeding colony. Only the 3 dogs with the most severe degree of thyroid histopathology showed a fall in the serum PBI values to <1.0 μg/100 ml on a low iodine diet, a subnormal 131I uptake, and a subnormal response of per cent thyroidal uptake of injected 131I to thyroid stimulating hormone. One dog with thyr...