Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta-Analysis
Association Between ALDH2 Polymorphism and Gastric Cancer Risk in Terms of Alcohol Consumption: A Meta-Analysis
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DOI：
10.1111/acer.14508
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发表时间：
2020-12-16
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影响因子：
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通讯作者：
Kim, Nayoung
中科院分区：
文献类型：
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作者：
Joo Kang, Seung;Shin, Cheol Min;Kim, Nayoung
背景：酒精可能增加胃癌风险。酒精可能是更致癌的人谁拥有不活跃的ALDH 2。本荟萃分析的目的是评估ALDH 2多态性是否会影响酒精诱导的胃癌发生。方法我们检索了PubMed、EMBASE和科克伦数据库，以确定2000年1月至2019年9月期间发表的相关文章。根据纳入和排除标准选择合格文章。结果共纳入7篇ALDH 2 rs671基因多态性病例对照研究，包括3,251例胃癌病例和4,943例对照。与活性ALDH 2（G/G基因型）相比，非活性ALDH 2基因型（G/A或A/A）与胃癌风险增加相关（比值比[OR] = 1.26，95%置信区间[CI]：1.04至1.52，p = 0.02，I-2 = 64%）。亚组分析显示，酒精摄入量不活跃的ALDH 2增加了中度至重度饮酒者患胃癌的风险（OR = 1.85，95%CI：1.52 ~ 2.25，p < 0.01，I-2 = 6%）高于不饮酒者或轻度饮酒者（OR = 1.19，95%CI：1.05 ~ 1.36，p < 0.01，I-2 = 6%）。中度/重度饮酒增加了ALDH 2不活跃个体的胃癌风险（OR = 2.23，95%CI：1.63 ~ 3.05，p < 0.01，I-2 = 30%）（OR = 1.40，95% CI：0.98 ~ 2.01，p = 0.07，I-2 = 85%）。中度/重度饮酒者比不饮酒者或轻度饮酒者更容易患胃癌，ALDH 2不活跃。
Background Alcohol may increase gastric cancer risk. Alcohol can be more carcinogenic in persons who possess inactive ALDH2. The aim of this meta-analysis was to evaluate whether ALDH2 polymorphism can affect alcohol-induced gastric carcinogenesis.Methods We searched the PubMed, EMBASE, and Cochrane databases to identify relevant articles published between January 2000 and September 2019. Eligible articles were selected according to inclusion and exclusion criteria. The data were analyzed using Review Manager 5.3.Results A total of 7 case-control studies on ALDH2 rs671 polymorphism consisting of 3,251 gastric cancer cases and 4,943 controls were included in the analysis. Inactive ALDH2 genotypes (G/A or A/A) were associated with an increased risk of gastric cancer (odds ratio [OR] = 1.26, 95% confidence interval [CI]: 1.04 to 1.52, p = 0.02, I-2 = 64%), compared with active ALDH2 (G/G genotype). Subgroup analysis by alcohol consumption showed that inactive ALDH2 increased risk for gastric cancer in moderate to heavy drinkers (OR = 1.85, 95% CI: 1.52 to 2.25, p < 0.01, I-2 = 6%) more than in nondrinkers or mild drinkers (OR = 1.19; 95% CI: 1.05 to 1.36, p < 0.01, I-2 = 6%). Moderate/heavy alcohol consumption increased gastric cancer risk in individuals with inactive ALDH2 (OR = 2.23, 95% CI: 1.63 to 3.05, p < 0.01, I-2 = 30%) more than those with active ALDH2 (OR = 1.40, 95% CI: 0.98 to 2.01, p = 0.07, I-2 = 85%).Conclusions The ALDH2 polymorphism modifies the risk of gastric cancer. Moderate/heavy drinkers are more susceptible to gastric cancer than non-drinkers or light drinkers with inactive ALDH2.