Diminished plasma free fatty acid clearance in obese subjects.
Diminished plasma free fatty acid clearance in obese subjects.
复制标题
肥胖受试者血浆游离脂肪酸清除率降低。
DOI：
10.1016/0026-0495(78)90025-2
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
R. Goldrick
中科院分区：
文献类型：
--
作者：
P. Nestel;T. Ishikawa;R. Goldrick
将肥胖受试者与瘦受试者进行比较，以确定先前报道的血浆游离脂肪酸(FFA)动力学紊乱的净转运(脂解)或清除(酯化)改变。这些测量是在持续葡萄糖摄取结束时持续持续输注1-14C-棕榈酸酯期间进行的，并在停止葡萄糖后6-8小时再次进行。在肥胖和瘦的受试者中，FFA的净转运被抑制到同样低的水平，尽管肥胖者的胰岛素浓度更高。然而，在瘦的受试者中，葡萄糖显著刺激了FFA的清除，而肥胖者在停糖期间和停糖后的清除率都很低。当停止血糖时，一些肥胖受试者的净转运增加得更快，程度也比瘦受试者更大。FFA流入的增加导致血浆甘油三酯水平仅在瘦的受试者中升高。这些研究表明，血浆游离脂肪酸的清除，可能表示肌肉和脂肪组织中的酯化作用，在肥胖时受到损害，不容易被葡萄糖和胰岛素刺激。然而，脂肪分解，即FFA的净转运，在肥胖者中是可以被葡萄糖和胰岛素抑制的，尽管这可能只有在胰岛素水平高于瘦身受试者时才能实现。
Obese subjects were compared with lean subjects to define the previously reported disturbance of plasma free fatty acid (FFA) kinetics in terms of altered net transport (lipolysis) or clearance (esterification). These measurements were made during prolonged constant infusions of 1 —14C-palmitate toward the end of sustained glucose ingestion and again 6–8 hr after stopping glucose. Net transport of FFA was suppressed to equally low levels in obese and lean subjects, though at the expense of higher insulin concentrations in the obese. Whereas in the lean subjects the clearance of FFA was significantly stimulated with glucose, the obese subjects showed low clearance rates both during and after stopping glucose. When glucose was stopped, net transport rose more rapidly and to a greater extent in some obese than in the lean subjects. The increased influx of FFA led to a rise in the plasma triglyceride level only in the lean subjects. These studies suggest that clearance of plasma FFA, probably denoting esterification in tissues such as muscle and adipose tissue, is impared in obesity and cannot be readily stimulated with glucose and insulin. Lipolysis, measured as net transport of FFA, however, is suppressible with glucose and insulin in the obese, though this might be achieved only at insulin levels that are higher than those in lean subjects.