Oxidation of cefazolin by potassium permanganate: Transformation products and plausible pathways
Oxidation of cefazolin by potassium permanganate: Transformation products and plausible pathways
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高锰酸钾氧化头孢唑啉：转化产物和可能的途径
DOI：
10.1016/j.chemosphere.2016.01.117
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发表时间：
2016-04-01
期刊：
影响因子：
8.8
通讯作者：
Du, Yuguo
中科院分区：
文献类型：
--
作者：
Li, Liping;Wei, Dongbin;Du, Yuguo
头孢唑啉被证明对高锰酸盐（Mn（VII）），一种常见的氧化剂在水预氧化处理发挥高反应性。在这项研究中，五个转化产物被发现分为三类，根据所包含的特征官能团：三（二）亚砜产品，砜产品和二酮产品的产品。产物分析表明，Mn（VII）在转化头孢唑林的过程中发生了硫醚氧化和不饱和C=C双键断裂两种反应。随后，根据所鉴定的产物和化学反应原理，提出了不同pH条件下的可能转化途径。更重要的是，与真实的地表水基质的模拟表明，所提出的头孢唑啉的转化途径可以在真实的水处理实践中重现。(C)2016爱思唯尔有限公司版权所有。
Cefazolin was demonstrated to exert high reactivity toward permanganate (Mn(VII)), a common oxidant in water pre-oxidation treatment. In this study, five transformation products were found to be classified into three categories according to the contained characteristic functional groups: three (di-)sulfoxide products, one sulfone product and one di-ketone product. Products analyses showed that two kinds of reactions including oxidation of thioether and the cleavage of unsaturated C=C double bond occurred during transformation of cefazolin by Mn(VII). Subsequently, the plausible transformation pathways under different pH conditions were proposed based on the identified products and chemical reaction principles. More importantly, the simulation with real surface water matrix indicated that the proposed transformation pathways of cefazolin could be replayed in real water treatment practices. (C) 2016 Elsevier Ltd. All rights reserved.