Responses of neurons in thalamic ventrobasal complex of rats to graded distension of uterus and vagina and to uterine suprafusion with bradykinin and prostaglandin F2 alpha.
Responses of neurons in thalamic ventrobasal complex of rats to graded distension of uterus and vagina and to uterine suprafusion with bradykinin and prostaglandin F2 alpha.
复制标题
大鼠丘脑腹基底复合体神经元对子宫和阴道分级扩张以及缓激肽和前列腺素 F2 α 子宫超灌注的反应。
DOI：
10.1016/0006-8993(93)91046-u
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发表时间：
1993
期刊：
影响因子：
2.9
通讯作者：
Gautron,M
中科院分区：
文献类型：
--
作者：
Guilbaud,G;Berkley,KJ;Benoist,JM;Gautron,M
本研究观察了氟烷/氧化亚氮麻醉和麻痹的动情期未孕大鼠腹侧基底复合体（VB）内及其附近的体细胞反应神经元对子宫角和阴道腔扩张程度增加以及对PGF 2 α和缓激肽（BK）子宫过度融合的反应。虽然单个神经元对子宫和阴道扩张的个体反应是特异质的，但作为一个组，神经元以分级的方式对分级的扩张作出反应，产生的刺激反应功能与对相同刺激作出逃避反应的清醒大鼠产生的刺激反应功能几乎相同[Berkley和Wood，Soc. Neurosci.摘要，15（1989）979; Berkley等人，神经科学学会摘要，16（1990）416]。此外，大多数神经元对PGF 2 α和BK反应强烈，对BK反应而不是PGF 2 α，可靠地先于也由这些致痛剂产生的“巨大”子宫收缩。这些结果表明，某些神经元在VB和附近可能作为一个群体参与了某些方面的疼痛所产生的女性生殖器官。然而，这些神经元对躯体和可能的其他内脏刺激的反应表明，它们可能参与内脏和躯体伤害感受的其他方面。
This study examined the responses of somatic-responsive neurons in and near the ventrobasal complex (VB) of halothane/nitrous oxide-anesthetized and paralyzed estrous virgin rats to increasing levels of distension of the uterine horn and vaginal canal and to uterine suprafusion with PGF2αand bradykinin (BK). While individual responses of single neurons to uterine and vaginal distensions were idiosyncratic, as a group the neurons responded in a graded fashion to graded distensions, producing stimulus-responses functions nearly identical to those produced by conscious rats making escape responses to the same stimuli [Berkley and Wood,Soc. Neurosci. Abstr., 15 (1989) 979; Berkley et al.,Soc. Neurosci. Abstr., 16 (1990) 416]. In addition, most neurons responded vigorously to PGF2αand BK, with responses to BK but not PGF2α, reliably preceding the ‘giant’ uterine contractions that were also produced by these algogenic agents. These results indicate that certain neurons in and near VB may as a group be involved in some aspect of pain arising from female reproductive organs. The responses of these neurons to somatic and possibly other visceral stimuli, however, point to their potential additional involvement in other aspects of visceral and somatic nociception.