Plant Food Allergies: A Suggested Approach to Allergen-Resolved Diagnosis in the Clinical Practice by Identifying Easily Available Sensitization Markers
Plant Food Allergies: A Suggested Approach to Allergen-Resolved Diagnosis in the Clinical Practice by Identifying Easily Available Sensitization Markers
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植物性食物过敏：通过识别容易获得的致敏标志物在临床实践中解决过敏原的诊断的建议方法
DOI：
10.1159/000087352
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发表时间：
2005
影响因子：
2.8
通讯作者：
R. Asero
中科院分区：
文献类型：
--
作者：
R. Asero
背景：分子生物学技术已经鉴定出了植物性食品中的多种过敏原，但由于缺乏用于常规诊断的纯化食品蛋白，致敏过敏原的检测在大多数临床环境中仍然是一项几乎不可能完成的任务。食物过敏的过敏原解决诊断至关重要，因为每种植物源性食品可能含有多种不同的过敏原，这些过敏原表现出不同的物理/化学特征，强烈影响过敏的临床表现；此外，许多过敏原可能与植物学上不相关的蔬菜食品中存在的同源蛋白发生交叉反应。目的：通过回顾现有文献，本研究旨在检测临床实践中容易获得的特定植物性食物过敏原的致敏“标记”。结果：植物性食品中存在多种对不同过敏蛋白敏感的“标志物”，这些“标志物”在临床实践中可能有所帮助。针对蔷薇科植物和坚果过敏的患者建立了特定的算法。结论：缺乏先进分子生物学实验室帮助的临床变态反应学家可以利用一些具体的临床数据以及一些“标记”来完成正确诊断植物性食物过敏患者的艰巨任务，并为他们提供最佳的预防建议。
Background: Molecular biology techniques have led to the identification of a number of allergens in vegetable foods, but due to the lack of purified food proteins for routine diagnostic use, the detection of sensitizing allergens remains a nearly impossible task in most clinical settings. The allergen-resolved diagnosis of food allergy is essential because each plant-derived food may contain a number of different allergens showing different physical/chemical characteristics that strongly influence the clinical expression of allergy; moreover, many allergens may cross-react with homologue proteins present in botanically unrelated vegetable foods. Objective: Through a review of the available literature, this study aimed to detect ‘markers’ of sensitization to specific plant food allergens that are easily accessible in the clinical practice. Results: There are several ‘markers’ of sensitization to different allergenic proteins in vegetable foods that can be helpful in the clinical practice. Specific algorithms for patients allergic to Rosaceae and to tree nuts were built. Conclusion: Clinical allergologists lacking the assistance of an advanced molecular biology lab may take advantage of some specific clinical data as well as of some ‘markers’ in the difficult task of correctly diagnosing patients with plant food allergy and to provide them the best preventive advice.
影响因子：
14.2
作者：
Beyer, K;Bardina, L;Sampson, HA
通讯作者：
Sampson, HA
影响因子：
14.2
作者：
Teuber, SS;Dandekar, AM;Sellers, CL
通讯作者：
Sellers, CL
DOI：
10.1111/j.1432-1033.1997.t01-1-00334.x
发表时间：
1997-04-15
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Burks, AW;Shin, D;Bannon, GA
通讯作者：
Bannon, GA