Intranasal insulin improves memory in humans
Intranasal insulin improves memory in humans
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DOI：
10.1016/j.psyneuen.2004.04.003
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发表时间：
2004-11-01
影响因子：
3.7
通讯作者：
Kern, W
中科院分区：
文献类型：
--
作者：
Benedict, C;Hallschmid, M;Kern, W
以前的研究表明，胰岛素对记忆功能有明显的改善作用。为了研究与人类大脑胰岛素活性长期增加相关的记忆变化，我们使用了已知的胰岛素鼻内给药途径，该途径可使物质直接进入脑脊液室。基于先前的结果，表明边缘系统和海马区域中胰岛素受体的普遍性以及全身胰岛素给药的记忆改善，我们预期胰岛素鼻内给药主要改善海马依赖性声明记忆功能。此外，预期情绪会有所改善。我们在38名健康受试者（24名配偶）中进行了一项双盲受试者间比较，研究了8周鼻内给予胰岛素（人常规胰岛素4 x 40 IU/d）对陈述性记忆（单词列表的即时和延迟回忆）、注意力（Stroop测试）和情绪的影响。血糖和血浆胰岛素水平在安慰剂和胰岛素条件之间没有差异。鼻内胰岛素给药8周后，单词的延迟回忆显著改善（单词回忆，安慰剂组2.92 +/- 1.00，胰岛素组6.20 +/- 1.03，p < 0.05）。此外，接受胰岛素治疗的受试者报告了情绪增强的迹象，如愤怒减少（p < 0.02）和自信增强（p < 0.03）。结果表明，长期鼻内胰岛素给药对脑功能有直接作用，在没有全身副作用的情况下改善记忆和情绪。这些发现可能与阿尔茨海默氏症等记忆障碍患者的治疗有关。(C)2004爱思唯尔有限公司保留所有权利。
Previous studies have suggested an acutely improving effect of insulin on memory function. To study changes in memory associated with a prolonged increase in brain insulin activity in humans, here we used the intranasal route of insulin administration known to provide direct access of the substance to the cerebrospinal fluid compartment. Based on previous results indicating a prevalence of insulin receptors in limbic and hippocampal regions as well as improvements in memory with systemic insulin administration, we expected that intranasal administration of insulin improves primarily hippocampus dependent declaration memory function. Also, improvements in mood were expected. We investigated the effects of 8 weeks of intranasal administration of insulin (human regular insulin 4 x 40 IU/d) on declarative memory (immediate and delayed recall of word lists), attention (Stroop test), and mood in 38 healthy subjects (24 mates) in a double blind, between-subject comparison. Blood glucose and plasma insulin levels did not differ between the placebo and insulin conditions. Delayed recall of words significantly improved after 8 weeks of intranasal insulin administration (words recalled, Placebo 2.92 +/- 1.00, Insulin 6.20 +/- 1.03, p < 0.05). Moreover, subjects after insulin reported signs of enhanced mood, such as reduced anger (p < 0.02) and enhanced self-confidence (p < 0.03). Results indicate a direct action of prolonged intranasal administration of insulin on brain functions, improving memory and mood in the absence of systemic side effects. These findings could be of relevance for the treatment of patients with memory disorders like in Alzheimer's disease. (C) 2004 Elsevier Ltd. All rights reserved.