Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls
Randomised study of cognitive effects of iron supplementation in non-anaemic iron-deficient adolescent girls
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DOI：
10.1016/s0140-6736(96)02341-0
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发表时间：
1996-10-12
期刊：
影响因子：
168.9
通讯作者：
Brandt, J
中科院分区：
文献类型：
--
作者：
Bruner, AB;Joffe, A;Brandt, J
在美国，高达25%的青春期女孩缺铁。本双盲，安慰剂对照的临床试验评估了铁补充剂对认知功能的影响，在青少年女孩与非贫血性铁deficiency.Methods 716名女孩谁参加了四个巴尔的摩高中进行了筛选非贫血性铁缺乏（血清铁蛋白小于或等于12微克/L，血红蛋白正常）。98（13 . 7%的女孩患有非贫血性铁缺乏症，其中81人参加了试验。参与者被随机分配口服硫酸亚铁（650毫克，每日两次）或安慰剂8周。铁治疗的效果通过问卷调查和血液学和认知测试进行评估，这些测试在治疗开始前进行，并在干预后重复进行。我们使用了四种注意力和记忆力测试来衡量认知功能。结果在81名非贫血性缺铁的女孩中，78名（96%）完成了研究（每组39名）。5名女孩（3名对照组，2名治疗组）在干预期间发生贫血，并被排除在分析之外。因此，73名女孩被纳入符合方案分析。种族分布、平均年龄、血清铁蛋白浓度、血红蛋白浓度和认知测试分数在基线时没有显著差异。干预后血液学指标铁状态显着改善治疗组（血清铁蛋白27。三比十二。1 μ g/L，p
Background Up to 25% of adolescent girls in the USA are iron deficient. This double-blind, placebo-controlled clinical trial assessed the effects of iron supplementation on cognitive function in adolescent girls with non-anaemic iron deficiency.Methods 716 girls who enrolled at four Baltimore high schools were screened for non-anaemic iron deficiency (serum ferritin less than or equal to 12 mu g/L with normal haemoglobin). 98 (13 . 7%) girls had non-anaemic iron deficiency of whom 81 were enrolled in the trial. Participants were randomly assigned oral ferrous sulphate (650 mg twice daily) or placebo for 8 weeks. The effect of iron treatment was assessed by questionnaires and haematological and cognitive tests, which were done before treatment started and repeated after the intervention. We used four tests of attention and memory to measure cognitive functioning. intention-to-treat and per-protocol analyses were done.Findings Of the 81 enrolled girls with non-anaemic iron deficiency, 78 (96%) completed the study (39 in each group). Five girls (three control, two treatment) developed anaemia during the intervention and were excluded from the analyses. Thus, 73 girls were included in the perprotocol analysis. Ethnic distribution, mean age, serum ferritin concentrations, haemoglobin concentrations, and cognitive test scores of the groups did not differ significantly at baseline. Postintervention haematological measures of iron Status were significantly improved in the treatment group (serum ferritin 27 . 3 vs 12 . 1 mu g/L, p