Histamine neurons in the tuberomamillary nucleus: a whole center or distinct subpopulations?
Histamine neurons in the tuberomamillary nucleus: a whole center or distinct subpopulations?
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DOI：
10.3389/fnsys.2012.00033
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发表时间：
2012
影响因子：
3
通讯作者：
Passani MB
中科院分区：
文献类型：
--
作者：
Blandina P;Munari L;Provensi G;Passani MB
组胺轴突起源于下丘脑后叶的结节乳头核（TMN），支配几乎所有的中枢神经系统（CNS）区域。这一特征是一个紧凑的细胞群，纤维分布广泛，类似于其他胺系统，如去甲肾上腺素或5-羟色胺，并且与组胺在许多生理过程中的功能一致，包括调节睡眠-觉醒周期、食欲、内分泌稳态、体温、疼痛感知、学习、记忆和情绪。一个重要的问题是，这些不同的生理作用是否由不同的组胺神经元亚群。虽然组胺系统通常被认为是一个单一的功能单位，提供组胺整个大脑，证据开始积累有利于组胺神经元的异质性。这篇综述的目的是总结实验证据表明，组胺神经元是异质性的，组织成功能不同的电路，在不同的大脑区域的冲击，并显示选择性控制机制。这可能意味着组胺神经元的亚群根据其各自的起源和终末投射具有独立的功能。
Histamine axons originate from a single source, the tuberomamillary nucleus (TMN) of the posterior hypothalamus, to innervate almost all central nervous system (CNS) regions. This feature, a compact cell group with widely distributed fibers, resembles that of other amine systems, such as noradrenaline or serotonin, and is consistent with a function for histamine over a host of physiological processes, including the regulation of the sleep-wake cycle, appetite, endocrine homeostasis, body temperature, pain perception, learning, memory, and emotion. An important question is whether these diverse physiological roles are served by different histamine neuronal subpopulation. While the histamine system is generally regarded as one single functional unit that provides histamine throughout the brain, evidence is beginning to accumulate in favor of heterogeneity of histamine neurons. The aim of this review is to summarize experimental evidence demonstrating that histamine neurons are heterogeneous, organized into functionally distinct circuits, impinging on different brain regions, and displaying selective control mechanisms. This could imply independent functions of subsets of histamine neurons according to their respective origin and terminal projections.