A new quinoline derivative with cytotoxic activity from Streptomyces sp. neau50.
A new quinoline derivative with cytotoxic activity from Streptomyces sp. neau50.
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DOI：
10.1016/j.bmcl.2011.02.095
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发表时间：
2011-04
影响因子：
2.7
通讯作者：
Xiangjing Wang;Dian-Liang Gong;Jidong Wang;Ji Zhang;Chongxi Liu;W. Xiang
中科院分区：
文献类型：
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作者：
Xiangjing Wang;Dian-Liang Gong;Jidong Wang;Ji Zhang;Chongxi Liu;W. Xiang
从内生真菌链霉菌Streptomycessp.neau50中分离得到一个新的喹啉衍生物8-（3-甲氧基-3-甲基丁基）-2-甲基喹啉-4-羧酸甲酯（1），经波谱分析确定其结构。化合物1显示出对人肺腺癌细胞系A549的细胞毒性，IC 50值为29.3μgmL-1。
A new quinoline derivative, methyl 8-(3-methoxy-3-methylbutyl)-2-methylquinoline-4-carboxylate (1), was isolated from the endophytic strain Streptomyces sp. neau50, and the structure was elucidated by extensive spectroscopic analysis. Compound 1 showed cytotoxicity against human lung adenocarcinoma cell line A549 with an IC50value of 29.3μgmL−1.