Tespa1 is associated with susceptibility but not severity of rheumatoid arthritis in the Zhejiang Han population in China
Tespa1 is associated with susceptibility but not severity of rheumatoid arthritis in the Zhejiang Han population in China
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DOI：
10.1007/s10067-015-2900-7
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发表时间：
2015-04-01
影响因子：
3.4
通讯作者：
Sun, Hui
中科院分区：
文献类型：
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作者：
Yao, Yunliang;Zhang, Hui;Sun, Hui
动物模型的观察和实验研究表明，Tespa 1可能与B细胞功能和类风湿性关节炎（RA）的发病有关。我们假设Tespa1也可能在RA患者中发挥重要作用。为了验证这一假设，我们研究了77例RA患者和113例匹配的健康对照者的Tespa1基因的表达水平、基因多态性和启动子甲基化。我们发现，Tespa1的表达在低和中到高疾病活动性的RA患者中显著较低。此外，家族性（一级兄弟姐妹）但不是散发性RA患者在rs4758993位点与健康人有统计学显著差异。此外，我们在Tespa1启动子上发现了7个甲基化位点，但没有证据表明这些位点的甲基化与RA易感性之间存在关联。这些数据支持Tespa1在RA发病机制中的潜在作用。
Observational and experimental studies in animal models have shown that Tespa1 may be associated with B cell function and the onset of rheumatoid arthritis (RA). We hypothesized that Tespa1 may also play an important role in patients with RA. To test this hypothesis, we investigated the expression level, gene polymorphisms, and promoter methylation of the Tespa1 gene in 77 RA patients and 113 matched healthy controls. We found that the expression of Tespa1 is significantly lower in RA patients with both low and moderate-to-high disease activity. Moreover, patients with familial (first-degree siblings) but not sporadic RA have a statistically significant difference at the rs4758993 locus with healthy people. Furthermore, we found seven methylation sites on the Tespa1 promoter, but no evidence of the association between methylation at these sites and RA susceptibility. These data support a potential role for Tespa1 in the pathogenesis of RA.