ESTROUS CYCLE-DEPENDENT VARIATION IN AMPHETAMINE-INDUCED BEHAVIORS AND STRIATAL DOPAMINE RELEASE ASSESSED WITH MICRODIALYSIS
ESTROUS CYCLE-DEPENDENT VARIATION IN AMPHETAMINE-INDUCED BEHAVIORS AND STRIATAL DOPAMINE RELEASE ASSESSED WITH MICRODIALYSIS
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DOI：
10.1016/s0166-4328(89)80112-3
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发表时间：
1989-11-01
影响因子：
2.7
通讯作者：
CHA, JH
中科院分区：
文献类型：
--
作者：
BECKER, JB;CHA, JH
对于接受脑内微透析的自由活动的大鼠，确定了安非他明（AMPH）刺激行为和纹状体多巴胺（DA）释放的动情周期依赖性变化。与发情间期大鼠的反应相比，在AMPH后20分钟至100分钟期间，发情期大鼠纹状体中AMPH刺激的纹状体DA释放量更大（P < 0.05）。与发情间期的动物相比，发情期的动物也表现出较少的一般活动和较高的刻板行为强度（P < 0.05）。体外检查 AMPH 刺激的纹状体 DA 释放的发情周期依赖性差异的独立实验也发现，AMPH 刺激的纹状体 DA 释放在发情时比在发情间期更大（P < 0.05）。因此，纹状体 DA 的释放和 AMPH 诱导的行为受到卵巢激素的调节。发情期间对 AMPH 的反应性增强表明雌激素和/或黄体酮增强了纹状体 DA 对 AMPH 的反应。
Estrous cycle-dependent variation in amphetamine (AMPH)-stimulated behaviors and striatal dopamine (DA) release was determined for freely moving rats undergoing intracerebral microdialysis. There was greater AMPH-stimulated striatal DA release in the striatum of rats in estrus, during the period from 20 min to 100 min post-AMPH, compared with the response of rats in diestrus (P < 0.05). Animals in estrus also showed less general activity and greater intensity of stereotyped behaviors than did animals in diestrus (P < 0.05). Independent experiments examining estrous cycle-dependent differences in AMPH-stimulated striatal DA release in vitro also found that AMPH-stimualted striatal DA release was greater on estrus than on diestrus (P < 0.05). Thus, striatal DA release and behaviors induced by AMPH are modulated by ovarian hormones. The heightened responsiveness to AMPH during estrus suggests that estrogen and/or progesterone potentiate the striatial DA response to AMPH.