Roseolovirus molecular biology: recent advances.
Roseolovirus molecular biology: recent advances.
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DOI：
10.1016/j.coviro.2014.10.004
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发表时间：
2014-12
影响因子：
5.9
通讯作者：
Pellett PE
中科院分区：
文献类型：
--
作者：
Krug LT;Pellett PE
Human herpesviruses 6A, −6B, and −7 (HHV-6A, −6B, and −7) are classified within the roseolovirus genus of the betaherpesvrus subfamily. Most humans likely harbor at least two of these large DNA viruses, and 1% of humans harbor germline chromosomally integrated HHV-6A or HHV-6B genomes. Differences at the genetic level manifest as distinct biologic properties during infection and disease. We provide a brief synopsis of roseolovirus replication and highlight the unique properties of their lifecycle and what is known about the viral gene products that mediate these functions. In the nearly 30 years since their discovery, we have only begun to unlock the molecular strategies these highly evolved pathogens employ to establish and maintain chronic infections in humans.
