Cyclic peptides and depsipeptides from cyanobacteria: A review
Cyclic peptides and depsipeptides from cyanobacteria: A review
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DOI：
10.1007/bf01570074
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发表时间：
1996-02-01
期刊：
影响因子：
--
通讯作者：
Moore, RE
中科院分区：
文献类型：
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作者：
Moore, RE
在蓝绿藻（蓝藻）中发现了一系列结构新颖且具有生物活性的环肽和缩酚肽，其中一些化合物具有与海洋无脊椎动物天然产物相似的结构。这些环肽和缩酚肽中的大多数，例如微囊藻毒素和lyngbytoxins，可能仅用作生化研究工具，然而，少数具有开发成有用的商业产品的潜力。例如，隐藻素-1（一种来自发菜属 GSV 224 的新型微管组装抑制剂）对植入小鼠体内的多种实体瘤（包括多重耐药实体瘤）显示出令人印象深刻的活性，而 majusculamide C（一种来自 Lyngbya majuscula 的微丝解聚剂）显示出强大的杀真菌活性，可用于治疗国内植物和农作物的抗性真菌引起的疾病。
An elaborate array of structurally-novel and biologically-active cyclic peptides and depsipeptides are found in blue-green algae (cyanobacteria), Several of these compounds possess structures that are similar to those of natural products from marine invertebrates. Most of these cyclic peptides and depsipeptides, such as the microcystins and the lyngbyatoxins, will probably only be useful as biochemical research tools, A few, however, have the potential for development into useful commercial products. For example, cryptophycin-1, a novel inhibitor of microtubule assembly from Nostoc sp GSV 224, shows impressive activity against a broad spectrum of solid tumors implanted in mice, including multidrug-resistant ones, and majusculamide C, a microfilament-depolymerizing agent from Lyngbya majuscula, shows potent fungicidal activity and may have use in the treatment of resistant fungal-induced diseases of domestic plants and agricultural crops.