[New dammarane type triterpene with cyclization at the side chain from oxidative alkaline-degradation products of PQS].
[New dammarane type triterpene with cyclization at the side chain from oxidative alkaline-degradation products of PQS].
复制标题
DOI：
--
复制
发表时间：
2008-03
期刊：
影响因子：
--
通讯作者：
Yuan Huang;Ning Li;Xian Li;Lusha Gao;Dali Meng
中科院分区：
文献类型：
--
作者：
Yuan Huang;Ning Li;Xian Li;Lusha Gao;Dali Meng
为研究西洋参皂苷的氧化碱解产物，采用硅胶柱层析、Sephadex LH-20柱层析和重结晶等方法，从西洋参氧化碱解产物中分离得到两个化合物。经波谱分析确定其结构为(12R，20S，24R)-20，24；12，24-二环-24-去异丙基-丹马烷-3-β-醇(1)和(20S，24R)-20，24-环氧丹马烷-3-β-3，12-β，25-三醇(2)。化合物1和化合物2为首次从西洋参总皂苷碱解产物中分离得到的侧链环化的丹马烷型三萜化合物，化合物1为新化合物。
To study the oxidative alkaline-degradation products of PQS (Panax quinquefolium saponin), two compounds were isolated from the crude product of oxidative alkaline-degradation by silica gel column chromatography, Sephadex LH-20 column chromatography and recrystallized methods. On the basis of spectroscopic analysis, their structures were established as (12R, 20S, 24R)-20, 24; 12, 24-diepoxy-24-deisopropyl-dammarane-3beta-ol (1) and (20S, 24R)-20, 24-epoxydammarane-3beta3, 12beta, 25-triol (2). Compounds 1 and 2, dammarane type triterpene with cyclization at the side chain, were obtained for the first time from alkaline-degradation products of total ginsenosides of Panax quinquefolium L., compound 1 is a new compound.