A Detailed Multipoint MapofHumanChromosome4Provides Evidence forLinkage Heterogeneity andPosition-specifi c Recombination Rates
A Detailed Multipoint MapofHumanChromosome4Provides Evidence forLinkage Heterogeneity andPosition-specifi c Recombination Rates
复制标题
人类 4 号染色体的详细多点图谱为连锁异质性和位置特异性重组率提供了证据
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
S. Wood
中科院分区：
文献类型：
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作者：
R. Shiang;Ping Yang;Y. Nakamura;S. Wood
Summary Utilizing theCEPHreference panel andgenotypic datafor53markers, we haveconstructed a 20-locus multipoint genetic map ofhumanchromosome 4.NewRFLPs arereported forfourloci. Themap integrates ahigh-resolution genetic map of4pl6into acontinuous map extending to4q31andan unlinked cluster of three loci at4q35. The20linked markers forma continuous linkage groupof152cM inmales and202 cMinfemales. Likely genetic locations areprovided for25polymorphic anonymous sequencesand28 gene-specific RFLPs. Themap was constructed employing theLINKAGEandCRIMAPcomputational methodologies tobuild themultipoint map via a stepwise algorithm. A detailed 10-point map ofthe4pl6 region constructed fromtheCEPHpanel provides evidence forheterogeneity inthelinkage maps constructed fromfamilies segregating forHuntington disease (HD). Itadditionally provides evidence forposition-specific recombination frequencies inthetelomeric region of4p.
通过脂皮质素 2A (LPC2A) 检测 SacI 和 XbaI 多态性。
影响因子：
14.9
作者：
Leysens,NJ;Newkirk,NG;Murray,JC
通讯作者：
Murray,JC