GLYCEROL PRODUCTION IN SUBCUTANEOUS ADIPOSE-TISSUE IN LEAN AND OBESE HUMANS
GLYCEROL PRODUCTION IN SUBCUTANEOUS ADIPOSE-TISSUE IN LEAN AND OBESE HUMANS
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DOI：
10.1172/jci115756
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发表时间：
1992-05-01
影响因子：
15.9
通讯作者：
LONNROTH, P
中科院分区：
文献类型：
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作者：
JANSSON, PA;LARSSON, A;LONNROTH, P
为了估计正常人和肥胖人的局部皮下甘油产生率，在吸收后状态和摄入100 g口服葡萄糖后2 h测量静脉动脉化血浆甘油、皮下脂肪组织间质甘油以及脂肪组织血流量（ATBF，ml/100 g.min）。本文应用皮下微透析技术和γ-133清除法，对8名口服葡萄糖耐量试验正常的瘦型和8名肥胖型男性进行了研究。在吸收后状态下，瘦和肥胖受试者腹部和股部皮下脂肪组织中的间质甘油浓度分别为170 +/- 21 vs. 282 +/- 28 μ-M（P < 0.01）和156 +/- 23 vs. 225 +/- 12 μ-M（P < 0.05）。相应的动脉甘油水平为54 +/- 4 vs. 75 +/- 14-mu-M（NS）。瘦型受试者的腹部ATBF更大（3.2 +/- 0.6 vs. 1.6 +/- 0.3; P < 0.05），而两组的股骨ATBF相似（2.7 +/- 0.4 vs. 2.4 +/- 0.7）。瘦型和肥胖组腹部和股骨部位的估计平均局部甘油释放（μ mol/100 g.min）相似（分别为0.16 +/- 0.03 vs. 0.20 +/- 0.05和0.18 +/- 0.02 vs. 0.17 +/- 0.04）。我们的结论是，甘油生产从皮下组织增加肥胖，无论脂肪组织分布。这种增强是由于脂肪组织质量增加。
To estimate the regional subcutaneous glycerol production rate in normal and obese humans, the venous arterialized plasma glycerol, interstitial glycerol in the subcutaneous adipose tissue together with adipose tissue blood flow (ATBF, ml/100 g.min) were measured in the Postabsorptive state and for 2 h after ingestion of 100 g of oral glucose. Eight lean and eight obese men with normal oral glucose tolerance tests were investigated with the subcutaneous microdialysis technique and Xe-133 clearance. In the postabsorptive state, the interstitial glycerol concentrations in lean and obese subjects were 170 +/- 21 vs. 282 +/- 28 mu-M (P < 0.01) and 156 +/- 23 vs. 225 +/- 12-mu-M (P < 0.05) in the abdominal and femoral subcutaneous adipose tissue, respectively. The corresponding arterial glycerol levels were 54 +/- 4 vs. 75 +/- 14-mu-M (NS). Abdominal ATBF was greater in lean subjects (3.2 +/- 0.6 vs. 1.6 +/- 0.3; P < 0.05), whereas femoral ATBF was similar in both groups (2.7 +/- 0.4 vs. 2.4 +/- 0.7). Estimated mean local glycerol release (mu-mol/100 g.min) was similar in the lean and obese group (0.16 +/- 0.03 vs. 0.20 +/- 0.05 and 0.18 +/- 0.02 vs. 0.17 +/- 0.04) in the abdominal and femoral site, respectively. We conclude that glycerol production from the subcutaneous tissue is increased in obesity, irrespective of adipose tissue distribution. This enhancement is due to the increased adipose tissue mass.