Role of vascular endothelial growth factor in ovarian physiology and pathology
Role of vascular endothelial growth factor in ovarian physiology and pathology
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DOI：
10.1016/s0015-0282(00)00670-1
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发表时间：
2000-09-01
影响因子：
6.7
通讯作者：
Jaffe, RB
中科院分区：
文献类型：
--
作者：
Geva, E;Jaffe, RB
目的：回顾目前的文献血管内皮生长因子/血管通透性因子（VEGF/VPF）在卵巢的生理和pathology.Design的作用：进行计算机检索，以确定相关的体外和体内研究发表在英文。检索MEDLINE、Current Contents和Index Medicus，检索2000年1月以前的文献。结果：VEGF/VPF是一种血管生成因子，是一种强有力的血管内皮细胞有丝分裂原。在生殖生活中，VEGF/VPF在卵泡的周期性生长和黄体的发育和维持中起作用，介导卵巢血管生成。VEGF/VPF的表达和分泌受FSH和LH/hCG受体激活途径的共同诱导。结论：VEGF/VPF在卵巢内的表达和产生对正常生殖功能至关重要。血管生成缺陷可能导致多种疾病，包括无排卵和不孕、妊娠丢失、卵巢过度刺激综合征和卵巢肿瘤。（Fertil Steril（R）2000;74：429-38. (C)美国生殖医学会（American Society for Reproductive Medicine）。
Objective: To review the current literature on the role of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in ovarian physiology and pathology.Design: A computerized search was conducted to identify relevant in vitro and in vivo studies published in English. MEDLINE, Current Contents, and the Index Medicus were searched for studies published before January 2000.Result(s): VEGF/VPF is an angiogenic factor and a potent mitogen for vascular endothelium. During reproductive life, VEGF/VPF plays a role in the cyclic growth of ovarian follicles and corpus luteum development and maintenance, mediating ovarian angiogenesis. VEGF/VPF expression and secretion are induced by both FSH and LH/hCG receptor-activated pathways.Conclusion(s): VEGF/VPF expression and production within the ovary are critical for normal reproductive function. Defects in angiogenesis may contribute to a variety of disorders including anovulation and infertility, pregnancy loss, ovarian hyperstimulation syndrome, and ovarian neoplasms. (Fertil Steril(R) 2000;74:429-38. (C) 2000 by American Society for Reproductive Medicine.).