REPRODUCTION FAILURE IN MALES WITH CYSTIC FIBROSIS
REPRODUCTION FAILURE IN MALES WITH CYSTIC FIBROSIS
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DOI：
10.1056/nejm196807112790203
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发表时间：
1968-01-01
影响因子：
158.5
通讯作者：
HOLSCLAW, DS
中科院分区：
文献类型：
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作者：
KAPLAN, E;SHWACHMA.H;HOLSCLAW, DS
患有囊性纤维化的成年男性由于输精管的正常发育失败而不育，这一发现以前未被认识到。25名17岁以上的患者被发现患有无精症。精液量减少，比对照组酸性更强。果糖浓度降低。柠檬酸和酸性磷酸酶升高。手术和尸检标本显示输精管缺失。睾丸大小正常或缩小。附睾明显缩小或部分缺失。所有青春期后睾丸的组织学检查显示精子发生减少，精子形态频繁异常。临床检查证实了手术和尸检结果。在15名男性囊性纤维化结婚46年，只有一个后代的报告。相比之下，18名患有囊性纤维化的已婚妇女有9个孩子。
Adult males with cystic fibrosis are infertile because of failure of normal development of the vas deferens, a finding not previously recognized. Twenty-five patients over 17 years of age were found to have aspermia. Semen volume was reduced and was more acidic than that of controls. Fructose concentration was diminished. Citric acid and acid phosphatase were increased. Surgical and autopsy specimens showed an absent vas deferens. The testes appeared normal or diminished in size. The epididymides were markedly reduced or partially absent. Histologic examination of all postpubertal testes revealed decreased spermatogenesis with frequent abnormal sperm forms. Clinical examination confirmed the surgical and autopsy findings. Among 15 males with cystic fibrosis married for 46 years, only one offspring is reported. In contrast, 18 married women with cystic fibrosis have had nine children.