The effect of salbutamol on performance in endurance cyclists
The effect of salbutamol on performance in endurance cyclists
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DOI：
10.1007/bf02425500
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发表时间：
1996-05-01
影响因子：
3
通讯作者：
Jones, RL
中科院分区：
文献类型：
--
作者：
Norris, SR;Petersen, SR;Jones, RL
在15名训练有素的非哮喘男性自行车运动员中，研究了沙丁胺醇（S）对自行车运动成绩的影响。采用双盲、随机交叉设计，在每次试验前20分钟使用定量吸入器和喷雾器装置给予S或安慰剂（P）。S剂量为400 μ g（4喷），是正常治疗水平的两倍。在实际数据收集前一周，使受试者习惯于所有实验室程序。受试者在两周内的不同日期在S和P条件下进行了四次测试。这些措施包括最大摄氧量（VO2max）的测量（踏车测力计）与肺功能评估之前和之后，一个次最大（90%的释压阈值）的方波工作过渡从一个基地的无负荷自行车，60秒的修改Wingate测试，和一个模拟的20公里计时赛。在S和P条件之间，与有氧耐力或自行车性能相关的任何因变量均未观察到显著差异。这些结果支持其他发现，急性剂量（400 μ g）的S没有性能增强性能。
The effect of salbutamol (S) on cycling performance was examined in 15 highly trained non-asthmatic male cyclists. A double-blind, randomized crossover design was used with S or placebo (P) administered using a metered-dose inhaler and a spacer device 20 min before each testing session. The S dose was 400 mu g (four puffs), which is twice the normal therapeutic level. Subjects were habituated to all the laboratory procedures in the week prior to actual data collection. The subjects performed four tests under S and P conditions on separate days over 2 weeks. These included measurement of maximal O-2 uptake (VO2max) (cycle ergometry) with assessment of pulmonary function before and after, a submaximal (90% of ventilatory threshold) square-wave work transition from a base of unloaded cycling, a 60-s modified Wingate test, and a simulated 20 km time trial. No significant differences were observed in any of the dependent variables related to aerobic endurance or cycling performance between the S and P conditions. These results support other findings that an acute dose (400 mu g) of S has no performance-enhancing properties.