The Organization of Metabolic Reaction Networks: A Signal-Oriented Approach to Cellular Models
The Organization of Metabolic Reaction Networks: A Signal-Oriented Approach to Cellular Models
复制标题
DOI：
10.1006/mben.2000.0159
复制
发表时间：
2000-07-01
影响因子：
8.4
通讯作者：
Gilles, E. D.
中科院分区：
文献类型：
--
作者：
Kremling, A.;Jahreis, K.;Gilles, E. D.
复杂的代谢网络以大量的元件和众多的调控回路为特征。用数学模型描述这些网络需要定义将几个细胞过程组合在一起的功能单元。这里提出的方法是基于细胞功能单位可以直接分配给数学建模对象的想法。由于建议的建模对象已经定义了输入和输出，因此可以将它们与其他建模对象连接起来，直到最终覆盖整个过程。这种模块化的方法保证了生物学家和工程师的高透明度。引入了三个标准来划分功能单元。这些标准考虑了生理途径，相应基因的组织，以及观察到细胞系统可以被结构成显示信号转导和处理层次的单位。作为一个例子，在大肠杆菌中的碳分解代谢反应被作为一个功能单元分解代谢的成员来讨论。(C) 2000年学术出版社
Complex metabolic networks are characterized by a great number of elements and many regulatory loops. The description of these networks with mathematical models requires the definition of functional units that group together several cellular processes. The approach presented here is based on the idea that cellular functional units may be assigned directly to mathematical modeling objects. Because the proposed modeling objects have defined inputs and outputs, they can be connected with other modeling objects until eventually the whole metabolism is covered. This modular approach guarantees a high transparency for biologists as well as for engineers. Three criteria are introduced to demarcate functional units. The criteria consider the physiological pathways, the organization of the corresponding genes, and the observation that cellular systems can be structured into units showing a hierarchy of signal transduction and processing. As an example, the carbon catabolic reactions in Escherichia coli are discussed as members of a functional unit catabolism. (C) 2000 Academic Press