Response to Letters Regarding Article, "Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development".
Response to Letters Regarding Article, "Segmental Aortic Stiffening Contributes to Experimental Abdominal Aortic Aneurysm Development".
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对有关文章“节段性主动脉硬化有助于实验性腹主动脉瘤发展”的信件的回应。
DOI：
10.1161/circulationaha.115.018759
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发表时间：
2016
期刊：
影响因子：
37.8
通讯作者：
Dalman,Ro
中科院分区：
文献类型：
--
作者：
Raaz,Uwe;Zöllner,AlexanderM;Schellinger,IsabelN;Toh,Ryuji;Nakagami,Futoshi;Brandt,Moritz;Emrich,FabianC;Kayama,Yosuke;Eken,Suzanne;Adam,Matti;Maegdefessel,Lars;Hertel,Thomas;Deng,Alicia;Jagger,Ann;Buerke,Michael;Dalman,Ro
我们感谢Han博士和他的同事，以及Murakami博士和他的同事对我们的研究1的兴趣，并在实验和临床主动脉缩窄的背景下讨论我们提出的节段性主动脉僵硬的病理机制。我们怀着极大的兴趣阅读了一个替代性兔模型的报告，该模型将外部弹性蛋白酶应用与近端主动脉缩窄相结合，以模拟加速腹主动脉瘤的发展。2尽管实验性主动脉缩窄引起的狭窄后湍流可能对该模型中的主动脉扩张起关键作用，但主动脉缩窄也会导致节段性主动脉僵硬，因此可能在收缩期主动脉扩张期间产生大量轴向壁应力，我们认为这是早期腹主动脉瘤发展的关键驱动因素。
We thank Dr Han and colleagues, and Dr Murakami and colleagues, as well, for their interest in our study 1 and for discussing our proposed pathomechanism of segmental aortic stiffness in the context of experimental and clinical aortic coarctation.We read with great interest the report of an alternative rabbit model that combines external elastase application with proximal aortic coarctation to model accelerated abdominal aortic aneurysm development. 2 Although poststenotic turbulent flow caused by experimental aortic constriction may critically contribute to aortic dilation in this model, aortic coarctation also results in segmental aortic stiffness and may therefore generate substantial axial wall stress during systolic aortic expansion that we believe is a critical driver of early abdominal aortic aneurysm development.