Vascular permeability to plasma, plasma proteins, and cells: an update.
Vascular permeability to plasma, plasma proteins, and cells: an update.
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DOI：
10.1097/moh.0b013e3283386638
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发表时间：
2010-05
影响因子：
3.2
通讯作者：
Dvorak HF
中科院分区：
文献类型：
--
作者：
Dvorak HF
血管系统为组织提供营养，清除废物，并携带和引导白细胞到达炎症部位。为了实现这些功能，微血管调节小分子、血浆蛋白和炎性细胞的外渗。对这些事件负责的机制一直是深入调查的对象，而且往往存在争议。最近的进展有助于更好地理解不同类型和不同血管床中的微血管调节小分子和大分子及细胞通过的机制。作用显示为糖萼，小窝，pericytyes，S1P，和新发现的信号通路。血管通透性对于维持体内平衡是重要的，并且在急性和慢性炎症、伤口愈合和生长的肿瘤中大大增加。新的工作对负责调节渗透性的机制做出了重要贡献。
The blood vasculature supplies tissues with nutrients, clears waste products, and carries and directs leukocytes to inflammatory sites. To accomplish these functions, microvessels regulate the extravasation of small molecules, plasma proteins and inflammatory cells. The mechanisms responsible for these events have been the subject of intense investigation and, often, dispute. Recent progress has contributed to a better understanding of the mechanisms by which microvessels of different types and in different vascular beds regulate the passage of small and large molecules and cells. Roles are shown for the glycocalyx, caveolae, perictyes, S1P, and newly discovered signaling pathways. Vascular permeability is important for maintaining homeostasis and is greatly increased in acute and chronic inflammation, wound healing, and growing tumors. New work has contributed importantly to the mechanisms responsible for regulating permeability.