Is Location Everything? Regulation of the Endothelial CCM Signaling Complex.
Is Location Everything? Regulation of the Endothelial CCM Signaling Complex.
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DOI：
10.3389/fcvm.2022.954780
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发表时间：
2022
影响因子：
3.6
通讯作者：
Glading, Angela J.
中科院分区：
文献类型：
--
作者：
Swamy, Harsha;Glading, Angela J.
最近的进展稳步增加了已知参与脑海绵状血管瘤（CCM）发展的蛋白质和途径的数量。然而，由于我们对核心CCM蛋白（其功能丧失驱动CCM的发展）如何被调控的知识存在重大差距，我们将这些信息合成一个有凝聚力和准确的信号模型的能力是有限的。在这里，我们回顾了三种核心CCM蛋白，支架KRIT1， CCM2和CCM3的调控，重点是结合相互作用和亚细胞定位，它们经常控制支架蛋白的功能。我们强调了最近的工作，挑战当前的CCM复杂信号模型，并为未来的研究提供建议，以解决大量悬而未决的问题。
Recent advances have steadily increased the number of proteins and pathways known to be involved in the development of cerebral cavernous malformation (CCM). Our ability to synthesize this information into a cohesive and accurate signaling model is limited, however, by significant gaps in our knowledge of how the core CCM proteins, whose loss of function drives development of CCM, are regulated. Here, we review what is known about the regulation of the three core CCM proteins, the scaffolds KRIT1, CCM2, and CCM3, with an emphasis on binding interactions and subcellular location, which frequently control scaffolding protein function. We highlight recent work that challenges the current model of CCM complex signaling and provide recommendations for future studies needed to address the large number of outstanding questions.
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影响因子：
20.1
作者：
Detter MR;Snellings DA;Marchuk DA
通讯作者：
Marchuk DA
影响因子：
5.3
作者：
DiStefano, Peter V.;Glading, Angela J.
通讯作者：
Glading, Angela J.
影响因子：
20.3
作者：
Carmona, Guillaume;Goettig, Stephan;Chavakis, Emmanouil
通讯作者：
Chavakis, Emmanouil
影响因子：
3.5
作者：
DUBOVSKY, J;ZABRAMSKI, JM;WEBER, JL
通讯作者：
WEBER, JL
影响因子：
7.7
作者：
de Kreuk BJ;Gingras AR;Knight JD;Liu JJ;Gingras AC;Ginsberg MH
通讯作者：
Ginsberg MH