The amygdala as a hub in brain networks that support social life.
The amygdala as a hub in brain networks that support social life.
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DOI：
10.1016/j.neuropsychologia.2014.08.013
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发表时间：
2014-10
期刊：
影响因子：
2.6
通讯作者：
Barrett LF
中科院分区：
文献类型：
--
作者：
Bickart KC;Dickerson BC;Barrett LF
越来越多的证据表明，杏仁核是灵长类动物处理复杂社会生活需求的核心。在本文中，我们综合了啮齿动物、猴子和人类的现存解剖学和功能数据，描述了三个部分不同的大规模大脑网络的拓扑结构，这些网络锚定在杏仁核中，每个网络都支持有效管理社会互动和维持社会关系的独特功能。这些发现提供了一个强大的组成框架，可以将社会行为解析为部分不同的神经基础，这些神经基础在健康人中存在差异，在以社会障碍为特征的神经精神人群中（例如自闭症、反社会人格障碍和额颞叶痴呆）会瓦解或无法发展。
A growing body of evidence suggests that the amygdala is central to handling the demands of complex social life in primates. In this paper, we synthesize extant anatomical and functional data from rodents, monkeys, and humans to describe the topography of three partially distinct large-scale brain networks anchored in the amygdala that each support unique functions for effectively managing social interactions and maintaining social relationships. These findings provide a powerful componential framework for parsing social behavior into partially distinct neural underpinnings that differ among healthy people and disintegrate or fail to develop in neuropsychiatric populations marked by social impairment, such as autism, antisocial personality disorder, and frontotemporal dementia.