Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart
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DOI：
10.1007/978-94-007-2888-2_30
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Maier, Lars S.
中科院分区：
文献类型：
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作者：
Maier, Lars S.
本文综述了钙离子/钙调素依赖性蛋白激酶II（CaMKII）在心脏中的作用，并讨论了最近的研究结果。特别注意的是兴奋收缩偶联（ECC）和兴奋转录偶联（ETC）。由于CaMK II的表达和活性在心脏肥大、心力衰竭和心律失常期间在动物模型以及人心脏中均增加，因此暗示CaMK II的临床意义。
Aim of this review is to give an overview and discuss recent findings on the role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the heart. Special attention is drawn to excitation-contraction coupling (ECC) and excitation-transcription coupling (ETC). Because CaMKII expression and activity are increased in cardiac hypertrophy, heart failure, and during arrhythmias both in animal models as well as in the human heart a clinical significance of CaMKII is implied.