Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men.
Smoking, Smoking Cessation, and Measures of Subclinical Atherosclerosis in Multiple Vascular Beds in Japanese Men.
复制标题
日本男性在多个血管床中吸烟，戒烟和亚临床动脉粥样硬化的测量。
DOI：
10.1161/jaha.116.003738
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发表时间：
2016-08-29
影响因子：
5.4
通讯作者：
Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research GroupNakanoYasutakaOgawaEmikoMaegawaHiroshiMiyazawaItsukoMitsunamiKenichiNozakiKazuhikoShiinoAkihikoArakiIsaoTsuruTeruhikoToyamaIkuoOgitaHisakazuKuritaSouichiMaedaToshinagaMiyamatsuNaomiKitaToruKimuraTakeshiNishioYoshihikoNakamuraYasuyukiOkamuraTomonoriBarinas‐MitchellEmma J.M.EdmundowiczDanielOhkuboTakayoshiHozawaAtsushiOkudaNagakoHigashiyamaAyaNagasawaShinyaKitaYoshikuniMurakamiYoshitakaTakashimaNaoyukiKadowakiTakash
中科院分区：
文献类型：
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作者：
Hisamatsu T;Miura K;Arima H;Kadota A;Kadowaki S;Torii S;Suzuki S;Miyagawa N;Sato A;Yamazoe M;Fujiyoshi A;Ohkubo T;Yamamoto T;Murata K;Abbott RD;Sekikawa A;Horie M;Ueshima H;Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA) Research GroupNakanoYasutakaOgawaEmikoMaegawaHiroshiMiyazawaItsukoMitsunamiKenichiNozakiKazuhikoShiinoAkihikoArakiIsaoTsuruTeruhikoToyamaIkuoOgitaHisakazuKuritaSouichiMaedaToshinagaMiyamatsuNaomiKitaToruKimuraTakeshiNishioYoshihikoNakamuraYasuyukiOkamuraTomonoriBarinas‐MitchellEmma J.M.EdmundowiczDanielOhkuboTakayoshiHozawaAtsushiOkudaNagakoHigashiyamaAyaNagasawaShinyaKitaYoshikuniMurakamiYoshitakaTakashimaNaoyukiKadowakiTakash
吸烟是心血管疾病（CVD）的一个压倒性但可预防的风险因素，尽管东亚发达国家和发展中国家的吸烟率仍然很高。在1019名年龄在40至79岁之间的日本男性中，没有CVD，我们检查了吸烟状态，累积包年，每日消费量和戒烟时间与4个解剖学上不同的血管床亚临床动脉粥样硬化的横断面相关性，包括冠状动脉钙化，颈动脉内膜中层厚度（CIMT）和斑块，主动脉钙化（AoAC）和踝肱指数。目前吸烟、既往吸烟和从不吸烟者分别占32.3%、50.0%和17.7%。与从不吸烟者相比，目前吸烟者在所有4个循环中发生亚临床动脉粥样硬化的风险显著更高（如冠状动脉钙化>0的优势比为1.79 [95% CI为1.16-2.79]; CIMT >1.0 mm的优势比为1.88 [1.02-3.47]; AoAC >0的优势比为4.29 [2.30-7.97];和踝肱指数<1.1，1.78 [1.16-2.74]）和既往吸烟者在颈动脉和主动脉循环中的表现（CIMT >1.0 mm，1.94 [1.13-3.34];和AoAC >0，2.55 [1.45-4.49]）。在当前和既往吸烟者中均观察到包年和每日消耗量的剂量-反应关系，特别是与CIMT、颈动脉斑块、AoAC和踝臂指数的关系，当前吸烟者中即使少量包年或每日消耗量也与冠状动脉钙化和AoAC相关，而既往吸烟者中自戒烟以来的时间与所有动脉粥样硬化指数的较低负担线性相关。在日本男性中，吸烟与多个血管床的亚临床动脉粥样硬化密切相关，并且这些相关性随着戒烟后的时间而减弱。
Smoking is an overwhelming, but preventable, risk factor for cardiovascular diseases (CVD), although smoking prevalence remains high in developed and developing countries in East Asia. In a population‐based sample of 1019 Japanese men aged 40 to 79 years, without CVD, we examined cross‐sectional associations of smoking status, cumulative pack‐years, daily consumption, and time since cessation, with subclinical atherosclerosis at 4 anatomically distinct vascular beds, including coronary artery calcification, carotid intima‐media thickness (CIMT) and plaque, aortic artery calcification (AoAC), and ankle‐brachial index. Current, former, and never smoking were present in 32.3%, 50.0%, and 17.7%, respectively. Compared to never smokers, current smokers had significantly higher risks of subclinical atherosclerosis in all 4 circulations (eg, odds ratios for coronary artery calcification >0, 1.79 [95% CIs, 1.16–2.79]; CIMT >1.0 mm, 1.88 [1.02–3.47]; AoAC >0, 4.29 [2.30–7.97]; and ankle‐brachial index <1.1, 1.78 [1.16–2.74]) and former smokers did in carotid and aortic circulations (CIMT >1.0 mm, 1.94 [1.13–3.34]; and AoAC >0, 2.55 [1.45–4.49]). Dose–response relationships of pack‐years and daily consumption, particularly with CIMT, carotid plaque, AoAC, and ankle‐brachial index, were observed among both current and former smokers, and even a small amount of pack‐years or daily consumption among current smokers was associated with coronary artery calcification and AoAC, whereas time since cessation among former smokers was linearly associated with lower burdens of all atherosclerotic indices. Cigarette smoking was strongly associated with subclinical atherosclerosis in multiple vascular beds in Japanese men, and these associations attenuated with time since cessation.