Base-Mediated [3+4]-Cycloaddition of Anthranils with Azaoxyallyl Cations: A New Approach to Multisubstituted Benzodiazepines
Base-Mediated [3+4]-Cycloaddition of Anthranils with Azaoxyallyl Cations: A New Approach to Multisubstituted Benzodiazepines
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碱介导的邻氨基苯甲醚与氮杂烯丙基阳离子的 [3 4]-环加成：多取代苯二氮卓类药物的新方法
DOI：
10.1021/acs.orglett.9b02118
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发表时间：
2019-08-16
期刊：
影响因子：
5.2
通讯作者：
Zhao, Ming
中科院分区：
文献类型：
--
作者：
Feng, Juan;Zhou, Meng;Zhao, Ming
为快速获得多取代苯并二氮杂二氮类化合物，实现了氮氧基烯丙基阳离子与邻菲罗啉的[3+4]环加成反应。在不含过渡金属的条件下，多种邻菲罗啉和α-卤代异羟胺都是操作简单的有效底物。该方法具有反应条件温和、效率高、底物范围广、官能团相容性广等特点。
A new [3 + 4] cycloaddition of azaoxyallyl cations and anthranils has been achieved for rapid access to multisubstituted benzodiazepine derivatives. A variety of anthranils and alpha-halo hydroxamates were both effective substrates with simple operations under transition-metal-free conditions. The intriguing features of this method include its mild nature of the reaction conditions, high efficiency, broad substrate scope, and wide functional group compatibility.