Prevalence of hepatitis C virus antibody in a cohort of hemophilia patients.
Prevalence of hepatitis C virus antibody in a cohort of hemophilia patients.
复制标题
血友病患者群体中丙型肝炎病毒抗体的患病率。
作者：
D. Brettler;H. Alter;J. Dienstag;A. Forsberg;P. Levine
在新英格兰血友病中心（伍斯特，马萨诸塞州）随访的131例患者进行了丙型肝炎病毒（HCV）抗体检测。除两名患者外，所有患者均使用未进行病毒灭活的因子浓缩物;两名患者仅使用冷沉淀。HCV抗体阳性率为76.3%。HCV抗体阳性组和阴性组之间的年龄或使用的非热处理因子浓缩物的量没有显著差异。两组的转氨酶水平也没有显著差异。HCV抗体与抗B核心抗原抗体和抗人类免疫缺陷病毒抗体呈正相关。一组31例患者进行了两次HCV抗体检测，间隔35至71个月。在该亚组中，25例重复血清阳性，4例重复血清阴性，2例从血清阳性转为血清阴性。这些数据证实了以前的印象，即非甲非乙型肝炎是使用合并凝血因子浓缩物的主要后遗症。HCV感染可能是该人群中观察到的大部分慢性肝病的原因。对血浆捐献者进行抗HCV检测和改进病毒灭活方法应可防止新病例的发生。
One hundred thirty-one patients followed at the New England Hemophilia Center (Worcester, MA) were tested for antibody to hepatitis C virus (HCV). All but two had used factor concentrate that had not undergone viral inactivation; two patients had used only cryoprecipitate. The overall prevalence of HCV antibody positivity was 76.3%. There was no significant difference in age or the amount of non-heat-treated factor concentrate used between the group that was HCV antibody positive and negative. There was also no significant difference between aminotransferase levels in the two groups. There was a positive association between HCV antibody and the presence of antibody to hepatitis B core antigen and antibody to human immunodeficiency virus. A group of 31 patients were tested twice for HCV antibody at intervals of 35 to 71 months. In this subset, 25 were repeatedly seropositive, 4 were repeatedly seronegative, and 2 went from seropositive to seronegative. These data confirm the previous impression that non-A, non-B hepatitis is a major sequela to the use of pooled coagulation factor concentrates. HCV infection may account for most of the chronic liver disease observed in this population. Anti-HCV testing of plasma donors and improved methods of viral inactivation should prevent new cases from developing.