Reduced telomerase activity in human T lymphocytes exposed to cortisol
Reduced telomerase activity in human T lymphocytes exposed to cortisol
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DOI：
10.1016/j.bbi.2007.12.004
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发表时间：
2008-05-01
影响因子：
15.1
通讯作者：
Effros, Rita B.
中科院分区：
文献类型：
--
作者：
Choi, Jenny;Fauce, Steven R.;Effros, Rita B.
淋巴细胞端粒加速缩短与多种人类疾病有关，包括艾滋病毒病、唐氏综合征和心血管疾病。最近的研究结果表明，端粒长度减少也与慢性心理压力和情绪障碍有关。防止端粒缩短的端粒酶可以在T淋巴细胞中随着活化而上调，从而延缓端粒缩短。在这里，我们证明了人类T淋巴细胞暴露于皮质醇与端粒酶活性的显著降低有关，无论是在静息细胞的初次刺激还是在先前激活的细胞的二次刺激期间。在CD4和CD8 T淋巴细胞中都观察到这种作用，并与端粒酶催化成分hTERT的转录减少有关。这些发现提供了应激相关端粒长度损耗的潜在机制，并提示增强T淋巴细胞端粒酶活性的策略可能对慢性情绪应激情况下的免疫功能产生有益影响。(c) 2008爱思唯尔公司版权所有。
Accelerated telomere shortening in lymphocytes has been associated with a variety of human pathologies, including HIV disease, Down syndrome, and cardiovascular disease. Recent findings indicate that reduced telomere length is also associated with chronic psychological stress and mood disorders. Telomerase, which prevents telomere shortening, can be upregulated in T lymphocytes in concert with activation, thereby retarding telomere shortening. Here, we demonstrate that exposure of human T lymphocytes to cortisol is associated with a significant reduction in telomerase activity both during primary stimulation of resting cells and secondary stimulation of previously activated cells. The effect is observed in both CD4 and CD8 T lymphocytes, and is associated with reduced transcription of hTERT, the telomerase catalytic component. These findings provide a potential mechanism for stress-associated telomere length attrition, and suggest that strategies to enhance T lymphocyte telomerase activity may provide beneficial effects on immune function in situations of chronic emotional stress. (c) 2008 Elsevier Inc. All rights reserved.