Predicting the Complex Phase Behavior of Self-Assembling Drug Delivery Nanoparticles
Predicting the Complex Phase Behavior of Self-Assembling Drug Delivery Nanoparticles
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DOI：
10.1021/mp3006402
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发表时间：
2013-04-01
影响因子：
4.9
通讯作者：
Winkler, David A.
中科院分区：
文献类型：
--
作者：
Le, Tu C.;Mulet, Xavier;Winkler, David A.
两亲性溶致液晶自组装纳米材料在治疗和成像药物的递送中具有重要的应用。然而，关于掺入的药物对纳米颗粒结构的影响知之甚少。预测这些属性被广泛认为是棘手的。我们提出了三种药物输送载体的计算模型，在六种浓度和两种温度下装载了10种药物。这些模型预测了11种新药的相行为。随后的同步加速器小角X射线散射实验验证了预测。
Amphiphilic lyotropic liquid crystalline self-assembled nanomaterials have important applications in the delivery of therapeutic and imaging agents. However, little is known about the effect of the incorporated drug on the structure of nanoparticles. Predicting these properties is widely considered intractable. We present computational models for three drug delivery carriers, loaded with 10 drugs at six concentrations and two temperatures. These models predicted phase behavior for 11 new drugs. Subsequent synchrotron small-angle X-ray scattering experiments validated the predictions.