Resistivity profiles of wild-type, rd1, and rd10 mouse retina.
Resistivity profiles of wild-type, rd1, and rd10 mouse retina.
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DOI：
10.1109/embc.2015.7318692
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发表时间：
2015-08
期刊：
影响因子：
--
通讯作者：
Weiland JD
中科院分区：
文献类型：
--
作者：
Boshuo Wang;Weiland JD
视网膜的电阻抗是视网膜假体中的关键因素，决定了视网膜内电流流动和电刺激的电位分布。以往的视网膜电阻率测量仅限于健康视网膜，没有包括视网膜研究中常见而重要的动物模型--小鼠模型。这项实验研究测量了野生型，rd 1和rd 10小鼠的电阻率曲线，为计算模拟和预测建模研究提供了基础。本文用峰值电阻频率法测量了正常大鼠和鸡胚视网膜的电阻率剖面，其结果与前人的研究结果一致。视网膜变性影响轮廓的宽度，这与组织学测量结果一致。退化也导致较低的峰值电阻率。结果表明，在细观尺度下，电阻率主要受空间因素的影响，而在细观尺度下，重构对细胞水平的影响不明显。
Electrical impedance of the retina is a critical factor in retinal prostheses, determining the intraretinal current flow and potential distribution of electrical stimulation. Previous resistivity measurements in retina were limited to healthy retina, and didn’t include mouse models, a common and important animal model in retinal research. This experimental study measured the resistivity profiles of wild-type, rd1, and rd10 mice, providing basis for computational simulations and predictive modeling studies. The peak resistance frequency method has been utilized to measure the resistivity profiles of the retina cross section, and the results show agreement with previous studies in retina of normal rats and embryonic chicks. Retinal degeneration affects the width of the profile, which is in agreement with histological measurements. Degeneration also results in lower peak resistivity. The results indicate that, on the mesoscopic scale, resistivity is dominated by spatial factors, while influence of remodeling on the cellular level is not apparent under such scale.