ANTIGENIC RELATIONSHIPS BETWEEN IMMUNE GLOBULINS AND CERTAIN RELATED PARAPROTEINS IN MAN.
ANTIGENIC RELATIONSHIPS BETWEEN IMMUNE GLOBULINS AND CERTAIN RELATED PARAPROTEINS IN MAN.
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免疫球蛋白与人类中某些相关副蛋白之间的抗原关系。
DOI：
10.1084/jem.114.4.521
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发表时间：
1961-09-30
期刊：
影响因子：
--
通讯作者：
Stanworth DR
中科院分区：
文献类型：
--
作者：
Franklin EC;Stanworth DR
正常 19S γ-球蛋白、病理性巨球蛋白、β2A-骨髓瘤蛋白和 Bence Jones 蛋白的抗原特性已与 7S γ-球蛋白和通过凝胶扩散沉淀技术衍生的小 3.5S 单位进行了比较。这些研究表明，7S γ-球蛋白分子上负责与其他蛋白质发生交叉反应的决定基团与具有抗体结合位点的 7S γ-球蛋白的两个片段相关。 7S γ-球蛋白的抗原特异性将其与这些蛋白质中的每一种区分开来，这主要与富含己糖且不能与抗原结合的片段相关。然而，与某些副蛋白相比，还发现具有抗体结合活性的片段具有额外的抗原特异性。在兔 γ-球蛋白中发现类似的抗原关系表明，一些仅与 7S γ-球蛋白相关而不与其他免疫球蛋白相关的生物学特性可能存在于也带有蛋白质抗原特异性的片段中。
The antigenic properties of normal 19S γ-globulin, pathologic macroglobulins, β2A-myeloma proteins, and Bence Jones proteins have been compared with 7S γ-globulin and the small 3.5S units derived from it by gel diffusion precipitin techniques. These studies demonstrate that the determinant groups on the 7S γ-globulin molecule responsible for the cross-reaction with each of the other proteins are associated with the two fragments of 7S γ-globulin which have the antibody-combining sites. The antigenic specificity of the 7S γ-globulin which distinguishes it from each of these proteins is associated primarily with the fragment that is richest in hexose and can not combine with antigen. However when compared with certain of the paraproteins additional antigenic specificity was also found to reside in the fragments with antibody-combining activity. The finding of similar antigenic relationships in rabbit γ-globulins suggests that some of the biological properties associated only with the 7S γ-globulins and not with the other immune globulins may reside in the fragment which also carries the antigenic specificity of the protein.