Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count
Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count
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DOI：
10.1038/sj.bmt.1701655
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发表时间：
1999-04-01
影响因子：
4.8
通讯作者：
Weinberg, K
中科院分区：
文献类型：
--
作者：
Bolotin, E;Annett, G;Weinberg, K
IL-7由基质细胞产生，是主要的淋巴细胞和胸腺生成细胞因子，IL-7诱导未成熟胸腺细胞的增殖和分化，并通过诱导bcl-2表达来保护胸腺细胞免于凋亡。尽管已经描述了转化生长因子-β (TGF-β) 的下调，但对 IL-7 产生的调节尚不清楚。我们测量了 32 名因遗传性疾病（严重联合免疫缺陷（SCID）和地中海贫血）、再生障碍性贫血、急性淋巴细胞和非淋巴细胞白血病（ALL 和 ANLL）而接受 BMT 的儿童在骨髓移植（BMT）前后的血清 IL-7 水平。 SCID和ALL，即遗传性或获得性淋巴细胞减少症患者、地中海贫血和ANLL患者的IL-7水平正常。在BMT后8周内，SCID和ALL患者的IL-7水平随着绝对淋巴细胞计数（ALC）的增加而下降。地中海贫血和 ANLL 患者中未观察到 IL-7 水平发生可检测的变化，与年龄匹配的对照相比，患有 SCID 的小婴儿的 IL-7 水平最高。总之，数据表明，淋巴细胞减少患者的血清 IL-7 水平与患者年龄和绝对淋巴细胞计数 (ALC) 呈负相关。与 ALC 的负相关表明，基质生成存在直接调节，或更可能是分泌的 IL-7 与表达 IL-7 受体的淋巴细胞结合。
IL-7 is produced by stromal cells and is the major lympho- and thymopoietic cytokine, IL-7 induces proliferation and differentiation of immature thymocytes, and protects thymocytes from apoptosis by induction of bcl-2 expression. The regulation of IL-7 production is poorly characterized, although down-regulation by transforming growth factor-beta (TGF-beta) has been described. We measured the serum levels of IL-7 before and after bone marrow transplant (BMT) in 32 children undergoing BMT for genetic diseases (severe combined immune deficiency (SCID) and thalassemia), aplastic anemia, and acute lymphoblastic and non-lymphoblastic leukemia (ALL and ANLL), Prior to BMT, the highest IL-7 levels were observed in patients with SCID and ALL, ie those patients with genetic or acquired lymphopenia, Patients with thalassemia and ANLL had normal levels of IL-7, Over the 8 weeks following BMT, the IL-7 levels of patients with SCID and ALL fell as the absolute lymphocyte count (ALC) increased. No detectable change in IL-7 levels was observed in the patients with thalassemia and ANLL, Levels of IL-7 were highest in the young infants with SCID compared to the age-matched controls. Together, the data demonstrate that serum levels of IL-7 in lymphopenic patients are inversely related to patient age and the absolute lymphocyte count (ALC), The inverse relationship to ALC suggests that there is either direct regulation of stromal production or more likely, binding of secreted IL-7 to lymphocytes expressing IL-7 receptors.